Friday, October 18, 2019
The Importance of Reflection in Nursing Practice Essay
The Importance of Reflection in Nursing Practice - Essay Example This process, called a meta-cognitive process, is normally reflected in a number of our daily routines and activities. Thus when we have to attend a call from a patient in pain, what priority we accord to it will be determined by the values and beliefs we hold and how we assess the situation. Reflective learning calls for instilling of the critical nursing skills in nurses through participative and emancipative education. This in turn helps in empowering the practitioners to deal with contradictory situations. Such training implies learning continuously with regular evolutionary inputs. Daloz (1986) describes the characteristics of support and challenge and the ways in which they might combine to foster learning. He describes support as an affirming activity. When a teacher supports a learner, the teacher lets the learner know that the learner is cared about. White (1997) suggests that new knowledge and theory can be generated when a structured and analytical methodology is applied to reflect on experience. In general, reflective practices can be categorized in two types; Reflection-in-action is when someone is working, and learning at the same time i.e. being fully aware of he's doing. Reflection-on-action is learning in a simulated environment when the nursing practitioners are taught by their tutors with the help of practical. For example nursing calls for advice being offered to the relatives and friends of the patients. Nursing is a science as it requires studying the medical practices and science, but it's an art as well because working with different types of people requires an attitude of understanding the feelings and compassion. Profession of Nursing involves being well versed with the technical gadgets, bio-medical terms, clinical tests, test reports as well as psychology, since during the majority of the times, when doctors are not around, nobody from family or friend circle is nearby, a Nurse is supposed to be the bedside companion taking care of the person with all sincerity. During such times most of our behaviors represent a mixture o f influences from both implicit, subconscious activations, and conscious considerations. The profession often requires long hours of working and heavy workloads while dealing with a range of people from all walks of life. Therefore, reflection-in-action is observing the things and the surroundings from one point of view and then devising 'in-time' appropriate reflections. Therefore in my opinion the profession of nursing requires; Compassion for another's suffering and love for the feelings of their patients Very high ethical standards Commitment to their profession Good interpersonal communication ability Critical cognitive process based thinking ability Highest standards of integrity and honesty Dealing with difficult and often unpleasant circumstances Working in physically demanding and often stressful environment Continuous aptitude for learning throughout one's life. Schon (1983) therefore calls for a "reflective practicum" to be an integral part of professional education. Lamb & Huttlinger, (1989) advocates reflection has a method by which nurses can enhance their future prospects and research practices. Williams (2001) enlists the results of a survey
Thursday, October 17, 2019
Defining the Good Life Essay Example | Topics and Well Written Essays - 1000 words
Defining the Good Life - Essay Example Wealth, health, a life without sorrow and pain are some of what seem to give people satisfaction, one that is said to be a good life. Perhaps it is. For the Greeks, a good life is one that shows happiness. It is then a matter of getting the most of what one has. For instance, a person who is lacking in wealth, according to the definition of the Greeks, can still have a good life depending on how he lives his life. That certain individual can either live in misery which is the extreme opposite of a good life or live so that he would make his life worthwhile and productive, a life that is flourishing. Human flourishing is a wonderful parallelism of the Greeks to a good life because it is perhaps the most accurate or closest accurate definition. Growing well is indeed one of the measures that show how a life is well-lived. It is not just a matter of living in luxury but it is also how a person lives to acquire a luxurious life, having the virtues a good life brings. This means that, in the case of wealthy people, they should not just enjoy what they have but strive to maintain and grow their wealth. However during the process, they should also maintain ethical attributes to keep them proud and satisfied with their achievements. When a person progresses or gains more wealth through illegal means or by using and abusing other people; that individual will definitely feel ashamed of himself. In fact, people who prosper in such a manner always live in fear of government authorities or their rivals and the people they have hurt. They may live in luxury, have money to burn but they do not have a good life because of the absence of the virtues they should possess. As the famous Socrates said, ââ¬Å"The unexamined life is not worth living forâ⬠(facultyfiles.frostburg.edu). Indeed, when an individual does not examine himself, he tends to commit mistakes and repeats them time and again. Obviously, a life full of mistakes and without virtues is miserable and undesirabl e. It is not a good life. Being a philosopher, Socrates was actually pointing out to the critical examination of things, events and ideas, the contemplation, self-examination and open-minded wondering (facultyfiles.frostburg.edu) that lead to finding the reasons for everything. A good life is a life of reasonable reasons. Reasons abound but if they are well thought, they make sense and therefore show the energy put into it. However, when reasons are shallow, they often look and sound ridiculous, exposing the life of the person that is not worth living. In relation to the aforementioned discussion on having virtues, it is acquired by having a well-examined life. One who thinks about himself and knows his strengths and weaknesses would definitely be able to build up the strengths and work on his weaknesses in order for him to become a better person. For instance, when a person knows that he has talents in arts, he can do something to develop his gift and become skillful and successful regardless of his situations. A person who knows he is gifted but does nothing to improve it spends no time contemplating about what a privilege he has, has a life not worth living. Self-examination in itself is a virtue and indulging in it develops more virtues in an individual. For example, a man who examines himself develops honesty. It would be futile to examine oneââ¬â¢s self and deny what he sees because this will cause a person to lose his virtues instead of gaining them. However, if a man scrutinizes himself and recognizes and accepts his weaknesses and faults, positive changes follow which is the development of more virtues that show what a real good life
Week11 Essay Example | Topics and Well Written Essays - 250 words
Week11 - Essay Example The government has to develop constituents within its establishments that have been in charge of state-owned companies. These branches eventually outlive their usefulness thus a disadvantage to the government because then it would have to do away with them. This means many people will lose their jobs thus blame the government for its shortsightedness (The Economist Debate). The limitation to state capitalism is that it can only be productive in certain industries as chosen by the government while the rest remain out. However, this depends on the degree of management as well as the level of interference by the state in the operational matters of the industries involved. All in all, the success or failure of state capitalism depends on the state and countries should know their status before indulging themselves or else the economy would be disastrous. In this case, the private sector would suffer a lot as its fundamental liberties would undergo regression. A country such as China is undergoing fast, economic growth thanks to state capitalism. However, its exposure to fluctuations in the purchasing power of other economies makes it unstable and
Wednesday, October 16, 2019
Defining the Good Life Essay Example | Topics and Well Written Essays - 1000 words
Defining the Good Life - Essay Example Wealth, health, a life without sorrow and pain are some of what seem to give people satisfaction, one that is said to be a good life. Perhaps it is. For the Greeks, a good life is one that shows happiness. It is then a matter of getting the most of what one has. For instance, a person who is lacking in wealth, according to the definition of the Greeks, can still have a good life depending on how he lives his life. That certain individual can either live in misery which is the extreme opposite of a good life or live so that he would make his life worthwhile and productive, a life that is flourishing. Human flourishing is a wonderful parallelism of the Greeks to a good life because it is perhaps the most accurate or closest accurate definition. Growing well is indeed one of the measures that show how a life is well-lived. It is not just a matter of living in luxury but it is also how a person lives to acquire a luxurious life, having the virtues a good life brings. This means that, in the case of wealthy people, they should not just enjoy what they have but strive to maintain and grow their wealth. However during the process, they should also maintain ethical attributes to keep them proud and satisfied with their achievements. When a person progresses or gains more wealth through illegal means or by using and abusing other people; that individual will definitely feel ashamed of himself. In fact, people who prosper in such a manner always live in fear of government authorities or their rivals and the people they have hurt. They may live in luxury, have money to burn but they do not have a good life because of the absence of the virtues they should possess. As the famous Socrates said, ââ¬Å"The unexamined life is not worth living forâ⬠(facultyfiles.frostburg.edu). Indeed, when an individual does not examine himself, he tends to commit mistakes and repeats them time and again. Obviously, a life full of mistakes and without virtues is miserable and undesirabl e. It is not a good life. Being a philosopher, Socrates was actually pointing out to the critical examination of things, events and ideas, the contemplation, self-examination and open-minded wondering (facultyfiles.frostburg.edu) that lead to finding the reasons for everything. A good life is a life of reasonable reasons. Reasons abound but if they are well thought, they make sense and therefore show the energy put into it. However, when reasons are shallow, they often look and sound ridiculous, exposing the life of the person that is not worth living. In relation to the aforementioned discussion on having virtues, it is acquired by having a well-examined life. One who thinks about himself and knows his strengths and weaknesses would definitely be able to build up the strengths and work on his weaknesses in order for him to become a better person. For instance, when a person knows that he has talents in arts, he can do something to develop his gift and become skillful and successful regardless of his situations. A person who knows he is gifted but does nothing to improve it spends no time contemplating about what a privilege he has, has a life not worth living. Self-examination in itself is a virtue and indulging in it develops more virtues in an individual. For example, a man who examines himself develops honesty. It would be futile to examine oneââ¬â¢s self and deny what he sees because this will cause a person to lose his virtues instead of gaining them. However, if a man scrutinizes himself and recognizes and accepts his weaknesses and faults, positive changes follow which is the development of more virtues that show what a real good life
Tuesday, October 15, 2019
INTERNATIONAL STUDIES IN BUSINESS Assignment Example | Topics and Well Written Essays - 250 words - 2
INTERNATIONAL STUDIES IN BUSINESS - Assignment Example My classmate does not show clearly whether the point on U.S restricting trade explains hurting or helping the auto industry. Although from the example given, one can conclude that he or she was talking about hurting the auto industry because the example shows that restricting imports would reduce innovativeness of auto industry. My classmates second answer is partly correct and partly out of context in addressing the question. He or she is correct by saying that autoworkers will be helped by the USââ¬â¢s efforts to restrict imports. The fact that foreign auto companies have branches in the US means that employment is made available to the US citizens. I do not agree with the idea that foreign companies such as Honda and Toyota hire only Japanese workers. The point on sales in Honda and Toyota cars going down and influencing the industry is out of context because it does not relate to government restricting imports. The point on government influencing auto industry is also not clear by not mentioning whether the policies created regard imports and exports according to the question. The point on manufacturers being forced to build safer and fuel efficient cars is also out of context. I think my classmate misinterpreted the
Monday, October 14, 2019
Deception in Psychological research Essay Example for Free
Deception in Psychological research Essay Deception in psychological research usually entails tricking people so that the researchers can get the answers they need or ascertain why things happen the way they do. There are many controversial topics in psychology and all of them seek to explain the things in our environment and peopleââ¬â¢s behavior. One of these controversial topics is hypnosis usage under cognitive psychology. Hypnosis is a good way of assisting in repressed memories. It has assisted many people in therapeutic procedures but its effectiveness is sometimes questionable by others. Hypnosis as a way of facilitating repressed memories Hypnosis is a form of Recovered Memory Therapy that helps a person with memory relapse to recall information that they cannot remember. A person does not necessarily mean that someone is asleep. Therefore it is a state between being awake and asleep. Trances serve as an example of hypnotic functions. Though they serve similar purposes, trances need to be differentiated from hypnosis because they are done deliberately as used in clinical procedures to help people with memory loss or lapses to regain them. The sympathetic nervous system controls arousals while the parasympathetic nervous system relaxation. These two systems do not function at the same time. When people are in the hypnotic state, they give up their consciousness and accept the inner truth (Richard, 1998). A person can undergo a deep trance where a person or the hypnotist facilitates the process or a lighter trance referred to as self hypnosis which individuals can create by themselves. This is where a person creates their own visual memory via meditation, listening to soft music or some other ways while maintaining a certain level of consciousness. Negative hypnosis occurs when people are easily influenced by what others say and the things they are exposed to. If people are told that they are not able to do certain things and they believe in such comments, then there is a likely hood that they will not accomplish they thing they have been discouraged. This is what constitutes the negative hypnotic state. Therefore, hypnosis is about expectations. If a person has positive expectations, then they can achieve any thing that they set for themselves but if they are negative, they are more likely to fail at whatever they decide on. Health care practitioners can therefore enhance the well being of their patients by assisting them in increasing their positive expectations. Hypnosis is important in helping sick with psychogenic amnesia or people who have lost their blocked certain memories as a result of traumatic experiences. It has been seen to work well for such patients. Research has shown some cases like child sexual as well as physical abuse can be forgotten. Likewise, evidence of recovery of the memories has also been shown (APA, 2001). At first, when the memory is being got, it presents itself in bits and pieces therefore more sessions with the person have to be conducted so as to help in recovering the memory. Traumatic memories often present themselves in a different manner than ordinary experiences. This is because this form of extreme information can interfere with other brain functions. Studies have suggested that traumatic memories that have been recalled are just as accurate as the traumatic memories that have been forgotten. Case study To examine whether hypnosis is an effective way of facilitating repressed memories, a study was conducted by Widom and Morris in 1998. The study included 23 adults; 12 females and 11 males who had been exposed to childhood abuse experiences and had repressed memory lapse in over 15 years. This group underwent hypnotic therapy for a period of three months (Widom Morris, 1998). From the study, it was seen that the there is a difference in the way of recalling events between the women and the men. The women were willing to share the little pieces of information that they could recall but the men were not. This influenced the hypnotic procedures because little memory was collected on most of the males as compared to the women. As the sessions progressed, there were slight improvements in memory and this can be attributed to the intense impact of the traumatic experiences on the victims as was seem from those who managed to get some of their memory back. At the end of the study period, 53% of the women and 42% of the men had recovered their memory and were satisfied that it as true. A quarter of those studied who managed to get their memory back had rejected their results saying that they may be false while the remaining never really got their memory back but said that so far they were pleased with their lives and would not engage in any other tests. From the study, we can say that hypnosis does work and can help people regain the memory they have lost. As the process was underway, most of the patients had a positive change in their personality as they said that they were more engaged in community activities as they were encouraged by the test takers. At the end of the study period, approximately half of the patients had got their memory back and this shows that if the procedures are done well and for a longer period, then people with previous traumatic incidents that need recovery can gain their memory back. About 25% of the individuals said that they usually kept to them selves and this can be a contributing factor as they do not trust the therapists to help them recover the memory. Various studies have also shown that events in a personââ¬â¢s life influence their behavior as well as interpersonal relations with others. From the above case, the unwillingness of some clients to share basic information limited the process. Some of those who refused said that as much as they wanted to get their memories back, said that it would probably affect them in a negative way. If they did, the numbers would have definitely increased. ââ¬Å"There is conflict between the in formation a person wants to know and what they would like to forget all together. Some people may remember too much too little and this may be good or bad depending on the context they are presented (Herman, 1995). â⬠Nowadays, some people feel that there are not enough scientific research studies to back up the credibility of the various research memories. Others continue to say that one cannot completely tell whether the results got are true or of they are based on what the hypnotist has been telling them. Even when the patient who agrees that the memory that they got was false, their condition can be worse when they suffer Post traumatic Stress Disorder. Some fear the use of hypnotic procedures on children because it would affect them psychologically and this is not helping in improving their situation. â⬠This kind of therapy confuses the mind as a person cannot tell the difference between what is real and imaginative and this has further contributed to the destruction of families (Rivera, 1993). â⬠In addition, they can deny certain memories because of guilt, the need to protect their families or may be reacting according to the stress levels they have been exposed to. The False Memory syndrome Association says that they have a lot of cases that are taken to court have shown that that some therapists are liars as they implant false memories on their patients (Thierry Spence, 2004). With the increase in such cases, some judges refuse getting evidence that has been recovered through hypnotic procedures. ââ¬Å"Such methods of treatment have therefore also not been fully accepted in science as well as psychology (Schacter, 1996). â⬠In 1997, according to the U. S bureau of Justice statistics report on a survey of female inmates in jail, it was found that 36% of them had been abused when they were young and one third of them has been raped they were imprisoned. And further 16 case studies on child abused individuals for comparison was undertaken and it showed that about 15% of them were abused as children. This shows that as much as the experiences can be traumatic, not all of them are forgotten and if, they have been suppressed by the individual but they can be retrieved if proper therapy is used. Individuals can recollect a few things and these bits are necessary in the formation of the bigger picture. The few loopholes in research should not be a foundation for dismissing hypnosis in retrieving repressed memories. People have had serious accidents and this form of therapy has helped some who medication did not help in regaining their memories back. Hypnosis therapy is a powerful mechanism as it enables people to regain memories that they thought they could never regain as well as achieve certain goals they have set for themselves. ââ¬Å"This power and acceptance of hypnosis as a form of therapy is due to the fact that it deals with capabilities which appear to be beyond normal activities (Hopper van der Kolk, 2001). â⬠Moreover, it gives people power to discover their inner being and stop actions such as smoking, drinking and other forms if addictions. Hypnosis also serves as a motivation for peopleââ¬â¢s engagement in physical activities and aids in reducing stress. This kind of therapy is helping in treating illnesses and certain disorders (De Vos Louw, 2008). Hypnosis is also used as a form of therapy in children as a form of helping in changing their behavior and assisting in improving their health. In addition, hypnosis enhances personality enrichment by improving peopleââ¬â¢s self esteems, self confidence such that they get the courage to speak out in public when initially they could not. ââ¬Å"Weight loss motivation, healthy eating and exercise, better sleep for people with seeing disorders, controlling anger, and controlling peoples fears among other things (Thierry Spence, 2004). â⬠Reliability and Validity of Research The study was reliable because the results indicated the specific responses of the individuals and since the study sample was small, it was easier to monitor individual progress. This would not have been the case if it were a larger number. Those individuals who were found out to have been sexually abused when they were young said that that was a possibility and most knew the individuals further proving that the results were reliable and valid. In addition, the individuals all showed up for the sessions as required therefore the lack of memory recovery could not be attributed to not attending the sessions. On top of these, no form of biasness was seen as the procedures were made as standard as possible and all variables that needed to be controlled were checked. Conclusion Hypnosis therapy usage is acceptable in society has it has helped a lot of people in more than one way especially in facilitating repressed memories. After all, the main goal of the procedure is to assist in the well being of a person. These form of therapy needs to be supported in increasing its evidentiary weight such that these memories can be used as evidence in the courts of law. Clinicians as well as psychotherapists therefore need to be skilled in this area for them to be able to properly guide the procedure so that the clients can get true memories which are part o their whole being and without them they are not complete. References American Psychological Association (APA) 2001. Understanding Child Sexual Abuse Rivera, Joseph. Trauma searches plant the seed of imagined misery, The Sacramento Bee, May 18, 1993. Herman, J. L. (1995). Crime and memory. Bulletin of the American Academy of Psychiatry and the Law, 23, 5-17. H. M. De Vos and D. A. Louw (2008). Hypnosis-induced mental training programmes as a strategy to improve the self-concept of students Vol. 57, No. 2, Higher education journal 2008 Hopper, J. W. , van der Kolk, B. A. (2001). Retrieving, Assessing, and Classifying Traumatic Memories. Journal of Aggression, Maltreatment, Trauma, 4, 33-71; and Freyd, J. F. , DePrince, A. P. (Editors). Trauma and Cognitive Science (pp. 33-71). Binghamton, NY: Haworth Press. Richard, S. C. July 1, (1998). The magic of hypnosis: is it childs play? The Journal of Psychology Schacter, Daniel L. (1996). Searching for Memory the brain, the mind, and the past. New York, Basic Books. Thierry, KL, Spence MJ (2004). Contemporary hypnosis Widom, C. S. Morris, S. (1998). Adult recollections of childhood victimization: Childhood sexual abuse. Psychological Assessment, 8, 412-421.
Sunday, October 13, 2019
Puumala Virus (PUUV) Genome Analysis
Puumala Virus (PUUV) Genome Analysis HANTAVIRUS PAPER REVIEW Summary A key concern of any viral vaccine research is the tremendous genetic diversity of the virus Hantaviruses are etiological agents generally known to cause two distinct human diseases: kidney affecting disease and heart affecting disease, haemorrhagic fever with renal syndrome (HFRS) sometimes called Nephropaphia epidemica (NE) in Eurasia and Americas hantavirus pulmonary syndrome (HPS) respectively. These viruses are heterologous (heterologous transmission from animals to humans (zoonosis)) which belong to the hantavirus genus, family Bunyavidae normally they make up four genera Hantavirus, Orthobunyavirus,à Nairovirus, Phlebovirus and Tospovirus. The genome of hantaviruses consist of three segments which are negative-strand of RNA, small (S) 1821-1830 nucleotides (nt), medium (M) 3682 nt and large (L) 6530-6562 nt encoding for nucleocapsid (N) protein, glycoprotein molecule (GPC) Gn, Gc proteinsà and RNA-dependent RNA-polymerase, respectively. This study characterises the full genome of a Russian hantavirus discovered both in infected humans and small animals, Puumala virus (PUUV). PUUV is considered a prime etiological agent of hemorrhagic fever with renal syndrome sometimes referred to nephropaphia epidemica in Russia and Eurasia. Mostly, all hantavirus diseases in human have a fatality rate ranging from mild to severe with an intriguingly percentage rate from 0.1% up to 50%,à the symptom outcome of the diseaseà heavily depend on the geographic location of an infected person. Precisely, in the republic of Tatarstan, Russia the strain of Puumala virus has shown significance increase as human pathogens resulting to the acquiring of the status as emerging virus. PUUV in the republic of Tatarstan, Russia, has become a serious life-threatening hantavirus causing HFRS with high fatality rate of up to 12%, especially in the Volga region. The spectrum of illnesses caused by hantaviruses varies with the particular virus involved(Hantavirus infection: a global zoonotic challenge paper). It is reported that the high peak of Puumala virus comes with the high agricultural activities of this region during of which Bank vole mouse (Clethrionomys glareolus) the etiological agent of HFRS rapidly multiply. Normally, hantavirus, Puumala virus (PUUV) is transmitted to human by coming into contact with contaminated materials like faecal matter, blood dropped by an infected rodent and through aerosolised contaminated air and by bite of a carrier infected rodent. In the case of the strain of Puumala virus in the Republic of Tatarstan, Russia, the strain is dropped by notorious reservoir rodent specie found in the surrounding environment either near homes or in the fields, Bank vole mouse (Clethrionomys glareolus). It has to be noted here that most hantaviruses are transmitted to human by small animals themselves with an exceptional of Andes virus which can be transmitted from human to human. In South America the case of Andes virus has been reported to be transmitted from human to human. Intriguingly, other species of hantaviruses, Dobrava-belgrade (DOBV) virus with its sub-species isolated in Europe, and Tula virus (TULV) are seriously detected and isolated in Russian and know to cause hemorrhagic fever with renal syndrome (HFRS) and in Europe the syndrome is called Nephropaphia epidemica. Dobrava-belgrade is known to be associated with yellow naked-mouse (Apodemus flavicollis) this specie is the most life-threatening hantavirus. Other dobrava-belgrade species, DOBV-Af, DOBV-Aa and DOBV-Ap are associated with A. flavicollis (Af), A. agrarious (Aa) and A. ponticus (Ap) respectively. All these species cause HFRS from mild to severe mode of disease. PUUV form distinct phylogenetic leanage, in line with the natural host, bank vole (Clethrionomys glareolus). The strain of Puumala virus is heavily isolated in Ufa, Samara,..parts of Russia both in human and small animals, in human as they thrive causing the dangerous form of human disease, hemorrhagic fever with renal syndrome (HFRS) Introduction Hantaviruses If you hear a feminine voice thinks of a beautiful lady, what if this time the feminine voice is of a man [1]. Hantaviruses have been limited to the genus hantavirus under bunyaviridae family which give rise to several number of species viruses Puumala virus (PUUV) [2], Dobrava virus (DOBV), Tula Virus, puumala virus (PUUV) Saaremaa virus (SAAV), and Seoul virus (SEOV) are commonly know hantaviruses to be circulating in Europe and Russia [3-5]. However, the agent rodents Hantaviruses are morphologically classified as follows; order rodential, families crecitidae and muridae. Its now a known fact that rodents are not the only hantavirus reservoirs. Researchers have found hantaviruses insects which belong to the lipotyphra order, soriciodae familys and Talpidae[6]. Further, with the recently isolated Bat-borne Hantavirus in China, laibin virus ( LBV) chyroptera order has given a strong predictive assumption that hanataviruses could be found in other animals like cow, [6]. The black bea rd tomb bat hantaviruses isolated in china gave a discrete relation to the previously known hantaviruses. Heavily depending on the geographical location of an infected person, the outcomes of hantavirus infection are well classified human diseases: haemorrhagic fever with renal syndrome (HFRS) sometimes referred to nephropathia epidemical mostly in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) normally called hantavirus pulmonary syndrome in the Americas [7] (dissertation Nina Luteka 2010). [1] As the onset of the diseases advances the changes in the vascular permeability is highly noticed, defects in platelet function and acute thrombocytopenia intrinsically can also be observed which is associated with high fever and hemorrhage. However, with the global health threat of hantavirus it has triggered serious research mainly focusing on the vulnerability of the endothelial cells when attacked by hantaviruses. Needless to say, less viral cytopathic effect is observed on the endothelial cells after hantavirus infection. (dissertation Nina Luteka 2010). The mechanism underlying these drastically changes in platelet as the pathogen advances drastically pooling down the immune system and how the hantaviruses trigger interference in the immune system greatly remain futile and poorly understood. hantaviruses have been discovered in insects which acts as the host vector (HO2), hantaviruses in the reservoirs cause asymptomatic completely they do not show any symptom in the natural host. We characterized genome of puumala virus discovered both in human and rodents Diseases Hantaviruses are zoonotic viruses that infect human through rodents contact; in rodents they dont cause diseases but when human come into contact with infected rodent through smelling the excretes or inhalation of infected hair from the rodents induces human diseases known as; Hemorrhagic fever with renal syndrome found in Europe, the agent viruses for this disease are: Dobrava virus (DOBV)-Belgrade, Puumala, Saaremaa, Sochi, and Seoul virus which is recently reported [8],these viruses are considered to be old world viruses, Bulgaria is one of the country were Hemorrhagic with renal syndrome is endemic but the virus has never been found in the natural rodent reservoir [8] however, Eastern Russia, Korea and China has the highest cases of HFRS caused by HTNV, SEOV, and ASV. Nephropathia epidemical diseases, a rodent disease found in human who gets infected after coming in contact with infected rodents and this disease has the symptoms of the hemorrhageic fever with renal syndrome which makes it to be referred to as same as hemorrhagic fever with renal syndrome [2] has continued to be life threatening in the republic of Tatarstan since its first identified in 1997. Epidemiological study on Nephropathia epidemical between 1997 and 2013 in the republic of Tatarstan, Russia gives an account that NE mostly affect male adults due to the agricultural activities during which myodes graleorus (bank vole) the natural reservoir of NE causing agents population increases [9]. It is revealed that the higher epidemic of hantaviruses in the Republic of Tatarstan is due to the supportive mating environment of small animals (bank voles) and increase in agriculture activities. Myodes galeorus shows high population rate during this time of agricultural activities and are a genetic variant prevalence for hantavirus in this region. However, the severity (or the fatality, the outcome) and the kind of disease or the infection involved mainly depends on several factors; The place infection take place The pathogenicity of the agents The genetic makeup (or the genetic predisposition of the host) Diversity of the agents [1] Geographical of the infection acquired Not all known rodent and insect hantaviruses cause disease in human [3] and the treatment for this dangerous hantavirus infection remains futile. The reasons for the variation of severity between virus species/genotypes and in individual patients are not yet known. Diverse determinants concerning virusand patient-specific characteristics may play a role in the pathogenesis. Differences in the use of entry receptors, in the regulation of cytokine response and in viral replication were described to be associated with pathogenicity [8-11]. Studies with genetic reassortants in vitro and in animal models suggest molecular determinants to be responsible for virulence [5, 12]. However, the speciesspecific factors of hantaviruses that are responsible for pathogenicity and clinical picture are not identified so far. Interestingly, the pathogenicity of related viruses of DOBV genotypes differs enormously with case fatality rates (CFRs) between 0.3%-0.9% for DOBV genotype Kurkino and 14.5% for DOBV genotype Sochi [13]. In addition to severe courses that are linked to specific virus species or genotypes, several serious cases were reported for infection with PUUV that usually causes a milder form of hantavirus disease [14, 15]. These infections often involve extrarenal manifestations [16, 17]. From (Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi paper) Hantaviruses evolution Hantaviruses within the family bunyaviridae are different from other member viruses in the sense that they are roboviruses (ROdent-BOrne viruses) signifying that they are hosted by small animals which act as the host reservoirs (vector). Other bunyaviridae virus members are arborviruses (arthropod viruses) transmitted by arthropod to human [10-12] . the circulation of hantaviruses throughout the continent has been triggerd by a number of activities which account for from human movements to the events of the world. These activities also account for the evolution of hantaviruses. However, it is believed that hantaviruses co-evolved together with their reservoirs animal more than 10 million years ago. The genetic diversity of hantaviruses came about by genetic mutation on the genome of the virus producing quasispecies which happened through deletions or insertion of new nucleotides. It is further, shown that the genetic diversity came about by reasortments of the same two viruses genome within the host and by the homologous recombination of the viruses with each other [12-14]. Evolution of hantavirus in the host (rodents) depends on the number of factors which greatly help them to thrive as they live within the host rodents or insects these factors include: the destict environment which act as a life supporting of rodent, there events that are believed to contribute to the evolvement of different kind of rodents, such as glaciations events.à Deglaciation events triggered the movements of rodents in the northern hemisphere southern hemisphere as the small animals migrated from one place to the other caused mutation to occurred in the host themselves and equally in the strain producing distinct kind of hantaviruses in the end causing permanent genetic variations in the population of the hantaviruses. Needless to say, human do not act as the host range of hantaviruses instead they are dead-end point of hantaviruses. Thereafter, hantaviruses do not evolve after inf ecting human vectors, its either they die together with the an infected body or they are wiped off from the human body.[11] Symptoms PUUV -circulating in Northern and Central Europe, Baltics, the part of Russia Europe and the Alpe- Adrian region; High fever Back pain Renal impairment DOBV- mostly circulating in Balkan countries and Alped-Adrian region has the following symptoms Severe illness Hemorrhage High fever Acute renal failure Dialysis may be required Fatality rate reaches 10% PUUV -circulating in Northern and Central Europe, Baltics, the part of Russia Europe and the Alpe- Adrian region; High fever Back pain Renal impairment Structure (morphology) The new era of elucidating the etiological agent of human disease hemorrhagic fever with renal syndrome (HFRS), emerged when the strain of puumala virus was isolated from the Bank vole (Clethrionomys glareolus) in Europe 199.., and the discovery of the four canners hantavirus in USA 1996. However, thanks to the famous and prolonged scientific work of Lee at el who isolated the first agent of Korean hemorrhagic fever, hantaan virus, from the autopsy lungs of striped field mice (apodemus agrarius) in 1978 after two decades of work [15]. Hantaviruses virion is lipid enveloped, covered and protected by polymorphic protein membrane nucleoprotein. The virion of hantavirus species are spherical shaped 80-110 nm in diameter [16-19]. Tripartite segmented negative-sense single stranded RNA genome comprising small (S), medium (M) and large (L) [20-22]. Small (S)-segment is the smallest segment and encodes for the nucleoprotein of 1821-1830 nucleotides the protein have 433 amino acids (aa) [22-2 4]. Medium (M)-segment encodes for the glycoprotein, large (L)-segment encodes for the RNA dependent RNA-polymerase (RdRp), of 3682 nt the glycoprotein precursor which covers the medium segment has 1148 amino acid, RdRp have 2156 aa, respectively [22-24] [6-10]. Furthermore, the small (S) segment however, has further an overlapping open reading frame (ORF) with a putative NSs protein of 90 aa [16, 20, 22, 24, 25] The lipid envelope bounded with viral glycoproteins covers nucleocapsids and RNA dependent RNA-polymerase.à Transmission The transmission of hantaviruses is done horizontally in specific human become affected by inhalation contaminated air, smelling of excreta of infected rodents and by direct contact with infected rodents. This can be realized through different situations: first domestication situation were an infected rodent happen to be in the house and leave some excreta, when in habitant come into contact with these materials they become infected, secondly through camping and agriculture this kind of situation amount to 70% of all kind of situation where people become infected. Natural reservoir Puumala virus is known to be harbored by the wild small animal called bank vole, myodes glareolus, DOBV, yellow field mouse; apodemus flavicollis, HTNV and a SAAV striped field mouse, apodemus agrarius (koreae and agrarius, respectively). SOCHV caused by black sea mouse, Apodemus ponticus; ASV Korean mouse field, apodemus penisulae; SEOV Norway rats, rattus norvegicus [3, 8] Hantavirus history Within a century modern world renascence between 1900 and 2000 the world witnessed the two major outbreak of diseases designated hemorrhagic fever with renal syndrome, sometimes referred to nephropathia epidenmica and cardiopulmonary syndrome all presumably caused by small animal rodents. The outbreak caused global human health threat before its agents where properly defined. It became an emerging potential human biological weapon disease because of its mass infections and its anthropoid vector which lead to the virus to thrive in its host reservoirs, without showing any sign of infection. The health hazardous outbreak led to the discovery of hantaviruses worldwide later categorized into two old and new world hantaviruses. Needless, to claim that hantaviruses evolutionarised only between this period, the signs and symptoms of these etiological agents disease in human hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome where long ago described noticed and can be seen in Chinese literature of 10th century and the Russian archives show the description of the disease as early as 1913 in Vladivastok. Lee et al, while working on the early reported severe or mild form of hemorrhagic fever, isolated the etiological agent believed to have induced high fever called Korean hemorrhagic fever near Hantaan River, Korea in 1978. The initial isolation of the agent of KHF led to the designating name hantavirus derived from the hantaan river the place where it was discovered. The highly published anticipated discovery of 1978 proved the earlier noticed hemorrhagic fever in 1951-1953 and gave the new era in the understanding of etiological agents human disease, HFRS and HPS in the world of health hazardous biological weapon. Needless, to say more than 3000 UN soldiers were diagnosed with high fever in the course of Korean War which lasted for 3- 4 years from 1951-53. Throughout, decades of research these zoonosis viruses were not well known However, afte r thorough research, until late 1981 the virus was known to have its own clade and belonged to bunyaviridae family, unlike other viruses hantaviruses research revealed that they did not have arthropod vector, hence they formed their own genus of hantavirus in the family bunyavidae and they exclusively maintained their residing reservoir rodents. Hence the new zoonotic Hantavirus emerged and was restricted to the old world viruses. This was proved wrong in 1993, the world experienced the outbreak of hantaviruses related diseases which triggered the malfunction of the respiratory system, high fever and severe heart damage in the unfortunate patients infected with hantaviruses. This lead to the conviction of world researchers that hantaviruses are actively circulating in the region earlier than there isolation in 1993, in the four corners of the Americas. Seoul virus transmitted by rat-borne mouse in Asia was described, an etiological agent specie of hantavirus causing HFRS in 1980 after the description of hantaan virus from striped field mouse (Apodemus agrarius) which started in 1976. This pioneered discovery came after a carefully long research and isolating the virus from the rat-borne mouse captured in the demilitarized battle field of Korea. The etiological agent of nephropaphia epidemical characterized in Europe was termed puumala virus, isolated from a bank vole striped field mouse initially called clethrionomys glareolus and later renamed myodes glareolus. 25 years later, the etiological agent of human disease hantavirus cardiopulmonary syndrome, Hantaan virus was identified fromâ⬠¦..after the four corner outbreak in the united state in 1993 and this led to the discovery of another hantavirus specie called no name virus later renamed Sin Nombre virus. It is estimated that there hantavirus cases yearly go beyond 1500000 gl obally, with almost half of these cases occurs in the peoples republic of china. Since the definition of hantaviruses more than 22 species of hantaviruses known to be pathogen in humans have been clearly categorized and accepted by the international Committee of Virus Taxonomy. With the suspicions of been engineered spread the Center of Disease Control and Prevention (CDC) warn of hantaviruses to be possible potential biological weapons. The world health organizationà in 1983 initiated the use of HFRS to represent all etiological symptomatic diseases believed to cause HFRS restricted in the Eurasia later called old world. Mostly, HFRS displayed symptoms such as chills, headache, high fever, generalized myalgia, back and abdominal pain and hemorrhagic presentation. Because of its epidemiological and worldwide distribution, hemorrhagic fever with renal syndrome initially had several names before 1983. Most terms used were epidemic hemorrhagic fever, Korean hemorrhagic fever and the alike symptomatic disease was called nephropathia epidemica in china, Korea and (USSR, Scandinavia and Europe) respectively. Hantaviruses clinical presentation Normally incubation of Hantaviruses human infection takes 2 to 3 weeks. The results of infection are the two distinct severe or mild forms of diseases: hemorrhagic renal with renal syndrome (HFRS) in the Eurasian countries and Hantavirus pulmonary syndrome in the American Countries. HFRS and Nephropaphia Epidemical are the severe form of hemorrhagic fever developed when infected with Euraisan kinds of Hantaviruses, patients present kidney failure, high fever, and internal bleeding as the main symptoms which results to the death of the patient[7]. Apart from kidney failure and high fever, affected humans present symptoms which include chills, vomiting, headache, dizziness, nausea, non-productive cough, gastrointestinal symptoms. A half percent of the patients display prolonged diarrhea, malaise and lightheadness, other presentations include back pain, arthralgias, abdominal pain, and shortness of breath, tachiypnea, tachycardia and fever. However, the main cause of death is the develo pment of disseminated intravascular congulation and internal bleeding. Table 1.à Clinical manifestation of Hemorrhagic Fever with renal syndrome [HemorrhagicFeverwithRenalSyndrome:PathogenesisandClinicalPicture Hong Jiang 1, HongDu1, LiM.Wang2, PingZ.Wang1* and XueF.Bai 1*] Incubation period takes 2-3 weeks HFRS Phase 1. Febrile Hemorrhage Flushing Headache Conjuctival injection Backache Albuminuria Azotema Present of antibodies IgM Eye pain Platelet decreased Petechial rash Immune complexes Fever Flushing Chills Conjuctival injection Myalgia Albuminuria Malaise Present of antibodies IgM Phase 2. Hypotension Kinin Complement activation Nausea Disseminated intrascular congulation Vomiting Vascular leakage Bleeding Acute shock Phase 3. Oliquric Disseminated intrasecular congulation (DI) Hypervolemia Kidney failure Pneumonia Phase 4. Diuretic Improved renal function Pulmonary complication Shock Death or improvement Phase 5. Convalescent Recovery period Table 2. Bunyavidae family classifications Common Reservoir Host Genus Common Species Country endemic Animal vertebrate bunyavirus Bunyamwera virus La Crosse virus Tahyna virus Akabane virus Oropouche virus Animal vertebrate Hantavirus Hantaan virus Sin Nombre virus Andes virus Puumala, Dobrava Americas Eurasia Animal vertebrate Nairovirus Dugbe virus Crimean-Congo hemorrhagic fever virus Nairobi sheep disease virus Eurasia, Africa Animal vertebrate Phlebovirus Rift Valley fever virus Rift Valley fever virus Sandly fever-Sicilian virus Plants Tospovirus Tomato spotted wilt virus Tomato spotted wilt virus Table 3: Hantaviruses genus classification Virus(serotype) Endemic area and reservoir distribution Disease Rodent vector Mortality (%) Puumala (PUUV) Eurasia (Old World) HFRS/NE Bank vole (Clethrionomys glareolus) 0.1-1 Dobrava-Belgrade (DOBV) South and East Europe, Balkan countries and the middle East (Old World) HFRS Yellow naked-mouse (Apodemus flavicollis) 9-12 Dobrava (DOBV) Central, East and north of Europe (Old World) HFRS Striped field mouse (Apodemus agrarius) Low Hantaan (HTN) Central, East and north of Europe, Eastern Russia,Tien Shan Mtns Caucasian,à China, north and south Korea (Old World) HFRS Striped field mouse (Apodemus agrarius) 10-15 Seoul (SEOV) World Wide (Old World) HFRS Rattus norvegicus and rattus 3-15 Tula (TUL) Europe (Old World) HFRS/? Microtus arvalis Low Amur Eastern Russia, Eastern Asia and Siberia (Old World) HFRS Korean field mouse (Apodemus peninsula) Low Andes (ANDV) South America (Argentina, Uruguay, Chile) (New World) HPS Oligoryzomys longicaudatus 35-56 Sin Nombre (SN) USA, Canada (New World) HPS Peromyscus maniculatus grassland 40-60 Prospect Hill(PH) (New World) USA, Canada HPS/? Mricrotus pennsylvanicus (Meadow vole) New York (NY) (New World) USA, Canada HPS Peromyscusà leucopus low Khabarosk (KHB) Russia , Asia (Old World) HFRS/? Microtus fortis (reed vole) low Thottapalayam (TPM) India, Afghanistan, Pakistan, China, Japan (Old World) HFRS/? Suncus murinus (musk shrew) Monongahela USA, Mexico, Canada (New World) HPS Peromyscus maniculatus (Deer mouse) low Black Creen Canal (BCCV) USA, Venesuala, Peru, (New World) HPS Sigmodon hispidus low Bayouà (BAYV) USA (Louisiana), (New World) HPS Oryzomys palustris Sigmodontinae (Rice rat) low Araraquara (ARAV) South America (Brazil) (New World) HPS Bolomys lasiurus low Muleshoe USA (New World) HPS Sigmodon hispidus Low Lechiguanas South America (Argentina), Brazil
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