Wednesday, October 30, 2019

The Gypsies And Their Journey Essay Example | Topics and Well Written Essays - 500 words

The Gypsies And Their Journey - Essay Example It constitutes the greatest impediment to civilization [sic]" (81). The treatment of the Gypsies in Europe is paradigmatic of the deleterious effects on civilization as a result of this instinctual disposition toward violence and aggression. There has been a paucity of recognition regarding the plight of the Gypsies, even after the Holocaust, when Hitler and his Nazi minions were responsible for the destruction of 1.5 million Gypsies (Wallia). The forgetting and abnegation of this tragedy in stark contrast to the attention given to the then concurrent predicament of the Jews have allowed for a continued and nearly unchecked level of violence against Gypsies. One work that has attempted to uncover the current attitudes and treatment of the Gypsies in Europe is Isabel Fonseca's Bury Me Standing: The Gypsies and their Journey. This paper will briefly examine how Freud's thesis regarding aggression is exemplified by Fonseca's presentation of Gypsies in Europe.  In a chapter entitled "A Social Problem," Fonseca examines the nature of conflicts and the uneasy existence between Romanians and Gypsies. She begins to note, however, interesting and oddly similar social phenomena occurring in both cultures, namely, getting swindled. Fonseca surmises, "But in truth swindling was so common in Romania that it was remarkable that the Gypsies, or anyone else, had managed to gain a reputation for dishonesty" (158). The subtle differences between Gypsy-swindles and Romanian ones are emblematic of the type of conditions that are sufficient for engendering racial hatred and conflict. In situations where adjoining territories or in this case, plots of land, are populated by different communities with some other similarities besides geographical, constant feuding, ridicule and violence are easily promulgated by what Freud terms, "the narcissism of minor differences" (72).

Monday, October 28, 2019

Diversity Organizations Worksheet Essay Example for Free

Diversity Organizations Worksheet Essay What has been the status of women in the United States throughout history? Throughout history women have been seen as less than to men. It has been rough on the women coming from minority groups because not only are they looked down on because of the group they are associated with but they are also women. For example, in the black community during the civil rights movement when blacks could not vote, and when they finally were allowed to vote, the women still could not. There has also been situations within the workforce when women could do a â€Å"manly job† but according to society they were not capable. †¢What is the status of women in the U.S. today? The status of women in the U.S. today has improved a lot. According to The State of Women in America, â€Å"women made up only about one-third of the workforce in 1969, women today make up almost half of all workers in the United States. Women are also stepping up to lead the country; a record number of women ran for public office in 2012, and a record-high percentage of women are serving in Congress.† Women today feel more apart, rather than an outcast. It is also clear to see that America is going to start to see changes with leaders of the country. Women are also paid equally to men according to their qualifications for the nature of the job. †¢What are some examples of concepts or constructions of masculinity and femininity that you see in society and in media? With media today, masculine males are seen as military men, or law enforcement officers, also most athletic figures. Men are shown to not to have emotion or care about women’s feelings.men are also portrayed to not care that much about their physical appearance. A man sitting back watching his favorite sports team and drinking beer on his favorite couch, while his wife is in the kitchen cooking and cleaning , as well as taking care of the children. Feminine in the media today is coming off as a petite, big breasted, and a fit body.it is seen on the famous lingerie commercials as well in movies associated with tough guys and fast cars. These commercials and movies give society a view that women should be a certain size and carry themselves a specific way. †¢Historically, what has been the social status of GLBT people? Historically, the social status of GLBT people has been very rough. It was hard for these individuals come out of the closet and be who they really are in front of the public eye. GLBT people have been discriminated against almost as much as African Americans. For example men who had a more feminine side could not show that because they feared that they may be beaten, or set aside from the rest of the men. These individuals believe because they live the way they choose they are unable to find jobs because companies would be ashamed to have them working for their company unless the owner is gay themselves. There has been a lot of changes throughout history to ensure that all Americans are being treated equal. †¢What is the status of GLBT people in the U.S. today? GLBT people in the U.S. today are beginning to experience a lot more equality. What this means is they are now starting to be allowed to marry one another. They are receiving a lot more protection in places like prisons, or jails. The overall awareness for these individuals has increased. Media has allowed for them to tell their stories, and there are some television shows about their lifestyles as well. Media has probably the largest impact in today’s society, so the fact that media is now coming around to promote the awareness is definitely a plus for GLBT people. †¢What are some social and political issues relevant to women and GLBT people in the U.S.? The social and political issues that surround this is that the women are becoming more lavish in today’s politics, and they are very tough within our political system. Hilary Clinton is a strong female in politics and has made a name for herself. There are many other women that have strong traits and similarities in politics just as Mrs. Clinton does and these women are just as valuable as the men are. GLBT people have also made a very recognizable name for themselves by using as many avenues as possible to strengthen their movement for equality. The media has been a big influence for these individuals and it is constantly on the rise. Gay marriage has been a big update on news channels all across America and is spreading like a rapid fire. This has given them the ability to come out and be who they are and not worry too much about what others have to say about them. There is still along path ahead of both women and the GLBT community but they are well on their way.

Saturday, October 26, 2019

Passing Essay -- Literary Analysis, Nella Larsen

Nella Larsen's Passing tells the story of the reconnection of two childhood friends whose lives take divergent paths. Through these characters Larsen weaves together a cautionary tale about the consequences of living a double life, and the harm associated with internalized racism. Through Clair and Irene, Larsen conveys to readers the consequences of desiring to live life as a bicultural individual during the early 20th century. Claire represents the archetypical character known as the tragic mulatto, as she brings tragedy to all those she encounters. Irene represents someone grappling with internalized racism; catalyzed by Claire's reentrance into her life. Larsen juxtaposes the two characters to demonstrate the inescapability of social regulations. Clare attempts to escape the social barriers placed upon African-Americans, and she does, but not without consequence. Through diction, tone, and imagery Larsen makes it luminous to readers that "passing" may seem glamorous, however, t he sacrifice one makes to do so is not without consequences for themselves and those they care about. Tragic mulatto characters such as Clare transport unforeseen horrors when they make the selfish decision to reinsert themselves back into the world they so desperately desired to flee. Larsen makes this point clear through the diction she uses when describing the self-esteem destruction Irene undergoes once Clare has reinserted herself into Irene's life, and the situations Irene finds herself as a direct result of Clare. Prior to Clare’s reentrance into her life Irene is a self-assured, independent, and confident woman; however, she soon turns self-conscious, dependent, and hesitant. Upon viewing Clare at the hotel Irene is struck by Clare’s ... ...s appealing it is not without consequence. Clare, and those who choose to pass, are not free to embrace their whole identity and will always remain a threat to those they come in contact. Clare exemplified the archetypal character of the tragic mulatto, as she bought tragedy to her own life and all those she came in contact. Clare’s presence forced Irene to contend with feelings of internalized racism, and thus feelings of inferiority. Through diction, tone, and imagery Larsen makes it luminous to readers that "passing" may seem glamorous, however, the sacrifice one makes to do so is not without consequences for themselves and those they care about. Larsen does not allow her readers to perch on the belief that once a member of the dominate group ones life is not without pain and suffering. Every action, even those that seem to make life easier, have consequences.

Thursday, October 24, 2019

Kodak and Fujifilm Essay

Growing up in a family that loves taking pictures and capturing moments. Kodak and Fujifilm played a huge role and are known companies to me and to many other households around the world. When it comes to the history and the competition few people know. The difference in management strategies plays a key role in the way the two companies’ embraced innovation. Complacency and slow adaptation dominated in Kodak Company while Fujifilm embraced innovation spirit and diversified in all aspects to ensure market relevance. Each of the company’s approach to ethics and social responsibility clearly reflects in both company’s profitability. With an aim to give back to the community and exercise ethical practices, production standards were maintained that satisfied consumers on both ends. A possible change of decision-making process that could embrace flexibility would be the best way to ensure diversity and innovation in any organization History George Eastman who was the founder of Kodak built a foundation of business on four basic principles: mass production at low cost international distribution, extensive advertising and focus on the customer at the age of fourteen he had to quit school and work to support his mother and two sisters. He took a job as an insurance messenger boy and was paying $3.00 a week. In 1874 at the age of 20 he became a junior clerk at the Rochester Saving Bank were there his salary tripled to $15.00 a week. In 1878 when Eastman took a trip to Santo Domingo in the Dominican Republic one of his  colleague that he record the trip. Eastman had fascination about the complicated with the compelling activity of photography. In 1879 Eastman invented an effective dry – plate formula and the machine that coat the plates in large numbers. By April 1880 he leased a small office in a building on State Street in Rochester, NY and began to manufacture dry plates. Henry A. Strong a local businessman investor and in 1881 Eastman resigned from the bank and Strong and him founded Eastman Dry Plate Company. The company did have a mishap that almost shut down the company when the dry plates that they sold went bad. Eastman came up with a quick solution to recall all of the bad plates and to replace them with good ones. In 1888 the Kodak came debuted the slogan stated â€Å"You press the button, we do the rest†. Kodak made the process of taking pictures and developing easy and accessible for everyone. In 1889 celluloid replaced paper film in the camera, and then by 1891 a factory was open in factory in Harrow in north London. The Brownie camera was introduced in 1900 which was named after the famous cartoon. In1925 Eastman retires at the age of 78 in 1932 he committed suicide . In 1930 Eastman Kodak Company launched on Dow Jones Industrial Average Index where in remain for the next 74 years. Throughout history Kodak has been used to capture historic moments such as Apollo 11 in 1969. Kodak was the first company in 1975 to build an actual working digital camera. By 2004 Kodak stop selling camera with film to increase popular digital alternatives. When CEO Antonio Perez took over in 2005 Kodak was the largest seller of digital camera in the U.S. revenue .By 2007 they fallen to fourth place and by 2010 was seventh place. By2011 Kodak’s shares fell more than 80% and has struggled to maintain market share and they were hit a huge pension costs for workers. With the changes in new technology Kodak was not prepare well. The company decided in 2012 to file bankruptcy protection. The company has worked out a credit plan with Citigrioup for 950 million to keep it afloat. History Fujifilm, formerly registered as Fujifilm Photo Film Co., Ltd. was started in 1934. They became established in the U.S. in 1965. Its core business much or less reflected the businesses that made Kodak prosper in the US:  photography and imaging. The company monopolized the Japanese market, ranked second placed in photography film usage after the US. Its ambitious management ventured overseas in the mid-90s without a fear of the already established Kodak. Despite its slow growth in the overseas markets, Fujifilm developed production bases outside its hub. A joint venture with Rank Xerox, a U.K based Limited company, strengthened Fujifilm’s position in the global market. A breakthrough was imminent in 1984’s Olympics held in Los Angeles which is Kodak’s home turf. Gradually, Fujifilm started eating into Kodak’s shares in the US due to near-equal products that were cheaper and actively marketed Fujifilm’s core businesses diversified faster with realization of looming transition by the management. Its imaging domain not only focused on personal, family and media moments but also diversified in the health sector. Its main businesses include film, photographic color paper, photographic equipment, medical equipment that included X-rays, and chemicals. More recently, Fujifilm’s early preparation to satisfy the fast-changing needs in the digital world ensured it widened its business scope to digital cameras, panel displays, printers, photocopiers and a variety of optical devices Management Approaches Kodak’s management approach on pursuing innovation by representing the latest innovation in the company’s consumer inkjet portfolio, marrying effortless connectivity with Kodak’s unique combination of high quality output and affordable ink. Kodak is committed to providing customers great value and lowest total ink replacement cost and exceptional cost per page. Fujifilm’s management approach on pursuing innovation by increasing a range of fields from imaging to medical systems. Fujifilm also became a much diversified company than Kodak by having a longer term vision in store and by investing a lot. Kodak’s Ethics and Social Responsibility Approaches Eastman Kodak Company is committed to operating in an environmental, ethical, and socially responsible manner. This commitment includes maintaining safe facilities and operations and providing goods which are safe and minimize environmental burdens throughout their business life cycle. Kodak’s Supplier  Standard sets an expectation for supplier health, safety, environmental, labor and ethical performances, and formalizes expectations in which they have always asked suppliers to commit to. In 2004 Kodak were praised in the â€Å"Business Ethics† magazine for anti-discrimination policies for gay, bisexual, and transgender employees. Kodak also believed in fair treatment of minorities and women and overall their employees. For years, Kodak has played a key role of social responsibility in Rochester, New York, where the headquarter is located. Charitable donations were for years made to the symphony hall and the orchestra club hosted at the same venue. This act paid off as the company maintained its customer and got even more customer for the way it gave back to the community. Further, tax abatements were considered for the company in its role of contributing huge sums to a community project. Kodak had given the drive of the donations where it is in favor of the shareholders’ interests. Acting otherwise rather than in the best interest of the company’s shareholders to increase their wealth and create good faith with the population would be deemed unethical by all measures. Quality products produced by the company were a result of an honest recruitment process. The company ensured it only recruited the best talent to ensure maintenance of quality assurance. The process involved was undeniably ethical and in a big part contributed to the profitability of the company. Kodak’s single-use recycling program ensured that over 70 million pounds of waste was avoided. This promoted Kodak’s image as an environmental friendly company, as well as ensured that it saved resources from having to acquire new raw material for manufacturing. Fujifilm’s Ethics and Social Responsibility Approaches Fujifilm holds in high esteem the ethical and social responsibilities it is obligated to provide. In 2004, the company formed action standards of ethical and social responsibility values the company had to comply. This was inclusive of all affiliates of the company, especially the double venture of Fuji Xerox. The guidelines have since been observed by every employee, uplifting the work standards and thus providing efficiency that translates  to profitability. . The company has formed an Ethics and Compliance hierarchy that is aimed at promoting ethical and corporate social responsibilities. Fujifilm believes compliance includes acting correctly in the light sense of common sense and ethics. Fujifilm compliance statements are in all aspects of their corporate activities they emphasize compliance and endeavor to create new value. If compliance requirements conflict with business profits or the demands of third parties, they give priority to compliance. An open, fair and clear corporate culture is the basis for all their activities Kodak and Fujifilm Adapting to Changing Market Conditions Kodak management failed to a new marketplace and new consumer attitudes, they focused on selling new product thinking that its new digital technology would cannibalize its film business. Instead of marketing the new technology the company held back from fear of hurting their film business. Most of Kodak’s strength was its brand and marketing, they began to fail when they underestimated the threat of the digital. Fujifilm management were prepared more to adapting to the changing in market, they realized that there was a need for them to develop an in-house expertise within new businesses. Fujifilm also focused on applying its technologies to new areas for instance today, Fujifilm has a medical imaging equipment business in which is growing quickly. Openness: A company with a management open to the democratic perspectives of other employees and customers is one of the best ways to adapt flexibility in the decision-making process. Openness will allow free flow and exchange of ideas, information, tasks and new perceptions of various processes (Sharfman & Dean, 1997). Recursiveness: This is a term used to define the repetitive process of formulation and implementation. Feedback is a significant part of this model as the decision-making team will always rely on the feedback, negative or positive to refine their decisions. This method goes against the perfect decision making hierarchy of problem definition, followed by search, analysis and eventually choice and implementation (Sharfman & Dean, 1997). Globalizing R&D: This is a model that would delocalize the centrality of r esearch and development. This would eventually increase the scope of decision makers’   perception. Limiting research to an area reduces the chance to get global feedback especially if a brand aims at conquering global markets. Companies today should build flexibility to back up its decision-making process in order to adapt to changing market conditions by these three recommendations: 1. Have an enterprise mindset that will be open to change. 2. Be able to adapt the company’s design to changing conditions. 3. Make decisions interactively using a variety of method.

Wednesday, October 23, 2019

Five Force Industry Analysis Essay

The Company distributes its products principally through third-party computer resellers. The Company is also continuing its expansion into new distribution channels, such as mass merchandise stores, consumer electronics outlets and computer superstores, in response to changing industry practices and customer preferences. The Company’s products are sold primarily to business and government customers through independent resellers, value-added resellers and systems integrators; to home customers through independent resellers and consumer channels; and to education customers through direct sales and independent resellers. In order to provide products and service to its independent resellers on a timely basis, the Company distributes its products through a number of Apple distribution and support centers. Business customers account for the largest portion of the Company’s revenues. Business customers are attracted to the Macintosh in particular for a variety of reasons, incl uding the availability of a wide variety of application software, the reduced amount of training resulting from the Macintosh’s intuitive ease of use, and the ability of the Macintosh to network and communicate with other computer systems and environments. Apple personal computers were first introduced to education customers in the late 1970’s. In the United States, the Company is one of the major suppliers of personal computers for both elementary and secondary school customers, as well as for college and university customers. The Company is also a substantial supplier to institutions of higher education outside of the United States. In the United States, the Company’s formal commitment to serve the federal government began in 1986 with the formation of the Apple Federal Systems Group. Although the Company has contracts with a number of U.S. government agencies, these contracts are not currently material to the Company’s overall financial condition or results of operations. Presently, the United States represents the Company’s largest geographic marketplace. The Apple USA organization, based in Campbell, California, focuses on the Company’s sales, marketing, and support efforts in the United States. Products sold in the United States are primarily manufactured in the Company’s facilities in California, Colorado, and Singapore, and distributed from facilities in California and Illinois. Approximately 45% to 46% of the Company’s revenues in recent years has come from its international  operations. The Company has two international sales and marketing divisions, consisting of the division and the Apple Pacific division. The Apple Europe division, based in Paris, France, focuses on opportunities in Europe as well as in parts of Africa and in the Middle East. Products sold by the Europe division are manufactured primarily in the Company’s facility in Cork, Ireland. The Apple Pacific division, based in Cupertino, California, focuses on opportunities in Japan, Australia, Canada, the Far East, and Latin America. Products sold by the Pacific division are manufactured primarily in the Company’s manufacturing and assembly facilities in California, Colorado and Singapore. A summary of the Company’s Industry Segment and Geographic Information may be found in Part II, Item 8 of this Form 10-K under the heading â€Å"Industry Segment and Geographic Information†, which information is hereby incorporated by reference. Raw materials Although raw materials, processes, and components essential to the Company’s business are generally available from multiple sources, certain key components are currently obtained from single sources. For example, certain microprocessors used in many of the Company’s products are currently available only from Motorola, Inc. Any availability limitations, interruption in supplies, or price increases relative to these and other components could adversely affect the Company’s business and financial results. Key components and processes currently obtained from single sources include certain of the Company’s displays, microprocessors, mouse devices, keyboards, disk drives, CD-ROM drives, printers and printer components, ASICs and other custom chips, and certain processes relating to construction of the plastic housing for the Company’s computers. In addition, new products introduced by the Company often initially utilize custom components obtained from onl y one source, until the Company has evaluated whether there is a need for an additional supplier. In situations where a component or product utilizes new technologies and processes, there may be initial capacity constraints until such time as the suppliers’ yields have matured. Materials and components are normally acquired through purchase orders, as  is common in the industry, typically covering the Company’s requirements for periods from 90 to 180 days. However, the Company continues to evaluate the need for a supply contract in each situation. If the supply of a key single-sourced material, process, or component to the Company were to be delayed or curtailed, its ability to ship the related product utilizing such material, process, or component in desired quantities and in a timely manner could be adversely affected. The Company’s business and financial performance could also be adversely affected, depending on the time required to obtain sufficient quantities from the original source, or to identify and obtain sufficient quantities from an alternate source. The Company believes that the suppliers whose loss to the Company could have a material adverse effect upon the Company’s business and financial position include, at this time , Canon, Inc., General Electric Co., Hitachi, Ltd., IBM, Motorola, Inc., Sharp Corporation, Sony Corporation, Texas Instruments, Inc., Tokyo Electric Co., Ltd., and/or their United States affiliates, and VLSI Technology, Inc. However, the Company helps mitigate these potential risks by working closely with these and other key suppliers on product introduction plans, strategic inventories, and coordinated product introductions. The Company believes that most of its single-source suppliers, including most of the foregoing companies, are reliable multinational corporations. Most of these suppliers manufacture the relevant materials, processes, or components in multiple plants. The Company further believes that its long-standing business relationships with these and other key suppliers are strong and mutually beneficial in nature. The Company has a supply agreement with Motorola, Inc. (see Exhibit 10.B.12 hereto). The agreement with Motorola continues for five years from January 31, 1992 unless otherwise mutually agreed in writing by the parties. The Company single-sources microprocessors from Motorola. The supply agreement does not obligate the Company to make minimum purchase commitments; however, the agreement does commit the vendor to supply the Company’s requirements of the particular items for the duration of the agreement. The Company has also from time to time experienced significant price incre ases and limited availability of certain components that are available from multiple sources, such as dynamic random-access memory devices. Any similar occurrences in the future could have an adverse effect on the Company’s operating results. Item 2. Properties The Company’s headquarters are located in Cupertino, California. The Company has manufacturing facilities in Fountain, Colorado, Sacramento, California, Cork, Ireland, and Singapore. As of September 30, 1994, the Company leased approximately 5.2 million square feet of space, primarily in the United States, and to a lesser extent, in Europe and the Pacific. Leases are generally for terms of five to ten years, and usually provide renewal options for terms of up to five additional years. Certain of these leased facilities are subject to the Company’s restructuring actions initiated in the third quarter of both 1993 and 1991. The amount of space leased by the Company may decline in the future as the leases for facilities subject to restructuring actions are terminated pursuant to agreements with landlords or expire as scheduled. The Company owns its manufacturing facilities in Fountain, Colorado, Cork, Ireland, and Singapore, which total approximately 920,000 square feet. T he Company also owns a 450,000 square-foot facility in Sacramento, California, which is used as a manufacturing, service and support center. The Company also owns the research and development facility located in Cupertino, California, and a centralized domestic data center in Napa, California which approximate 856,000 and 158,000 square feet, respectively. Outside of the United States, the Company owns a facility in Apeldoorn, Netherlands, which is used primarily for distribution, totaling approximately 265,000 square feet, in addition to certain other international facilities, totaling approximately 553,000 square feet. The Company believes that its existing facilities and equipment are well maintained and in good operating condition. The Company has invested in additional internal capacity and external partnerships, and therefore believes it has adequate manufacturing capacity for the foreseeable future. The Company continues to make investments in capital equipment as needed to meet anticipated demand for its products. Information regarding critical business operations that are located near major earthquake faults is set forth in Part II, Item 7 of this Form 10-K under the heading â€Å"Factors That May Affect Future Results†, which information is hereby incorporated by reference. Information regarding the Company’s purchase of its remaining partnership interest in Cupertino Gateway Partners, formed for the purpose of constructing the campus-type office facility that is now wholly owned by  the Company, may be found in Part II, Item 8 of this Form 10-K under the heading â€Å"Commitments and Contingencies†, which information is hereby incorporated by reference. â€Å"Other countries† consists of Canada and Australia. Prior year amounts have been restated to conform to the current year presentation. Net sales to unaffiliated customers is based on the location of the customers. Transfers between geographic areas are recorded at amounts generally above cost and in accordance with the rules and regulations of the respective governing tax authorities. Operating income (loss) by geographic area consists of total net sales less operating expenses, and does not include an allocation of general corporate expenses. The restructuring charge and adjustment recorded in 1993 and 1994, respectively, are included in the calculation of operating income (loss) for each geographic area. Identifiable assets of geographic areas are those assets used in the Company’s operations in each area. Corporate assets include cash and cash equivalents, joint venture investments, and short-term investments. 1995 Approximately 45% to 48% of the Company’s revenues in recent years has come from its international operations. The Company has two international sales and marketing divisions, consisting of the Apple Europe division and the Apple Pacific division. The Apple Europe division focuses on opportunities in Europe as well as in parts of Africa and in the Middle East. Products sold by the Europe division are manufactured primarily in the Company’s facility in Cork, Ireland. The Apple Pacific division focuses on opportunities in Japan and Asia; Australia and New Zealand; and the Caribbean region. Products sold by the Pacific division are manufactured primarily in the Company’s facilities in California, Colorado and Singapore. The Company distributes its products through third-party computer resellers, and is also continuing its expansion into various consumer channels, such as mass merchandise stores, consumer electronics outlets and computer superstores, in response to changing industry practices and customer preferences. The Company’s products are sold primarily to business and government customers through independent resellers, value- added resellers and systems integrators; to home customers through independent resellers and consumer channels; and to education customers through direct sales and independent resellers. In order to provide products and service to its independent resellers on a timely basis, the Company distributes its products through a number of Apple distribution and support centers. Raw materials Although certain raw materials, processes, and components essential to the Company’s business are generally available from multiple sources, key components and processes currently obtained from single sources include certain of the Company’s displays, microprocessors, mouse devices, keyboards, disk drives, printers and printer components, application- specific integrated circuits (â€Å"ASICs†) and other custom chips, and certain processes relating to construction of the plastic housing for the Company’s computers. Any availability limitations, interruption in supplies, or price increases relative to these and other components could adversely affect the Company’s business and financial results. In addition, new products introduced by the Company often initially utilize custom components obtained from only one source, until the Company has evaluated whether there is a need for an additional supplier. In situations where a component or product utilizes new technologies and processes, there may be initial capacity constraints until such time as the suppliers’ yields have matured. Materials and components are normally acquired through purchase orders, as is common in the industry, typically covering the Company’s requirements for periods from 90 to 180 days. However, the Company continues to evaluate the need for a supply contract in each situation. If the supply of a key single-sourced material, process, or component to the Company were to be delayed or curtailed, its ability to ship the related product utilizing such material, process, or component in desired quantities and in a timely manner could be  adversely affected. The Company’s business and financial performance could also be adversely affected, depending on the time required to obtain sufficient quantities from the original source, or to identify and obtain sufficient quantities from an alternate so urce. The Company believes that the suppliers whose loss to the Company could have a material adverse effect upon the   Company’s business and financial position include, at this time, Canon, Inc., General Electric Co., Hitachi, Ltd., IBM, Motorola, Inc., Sharp Corporation, Sony Corporation, Texas Instruments, Inc., and/or their United States affiliates, and VLSI Technology, Inc. However, the Company helps mitigate these potential risks by working closely with these and other key suppliers on product introduction plans, strategic inventories, and coordinated product introductions. The Company believes that most of its single-source suppliers, including most of the foregoing companies, are reliable multinational corporations. Most of these suppliers manufacture the relevant materials, processes, or components in multiple plants. The Company further believes that its long-standing business relationships with these and other key suppliers are strong and mutually beneficial in nature. The Company has also from time to time experienced significant price increases and limited availability of certain components that are available from multiple sources. Any similar occurrences in the future could have an adverse affect on the Company’s operating results. The Company has a supply agreement with Motorola, Inc. (see Exhibit 10.B.12 hereto). The agreement with Motorola continues for five years from January 31, 1992 unless otherwise mutually agreed in writing by the parties. The Company single-sources certain microprocessors from Motorola. The supply agreement does not obligate the Company to make minimum purchase commitments; however, the agreement does commit the vendor to supply the Company’s requirements of the particular items for the duration of the agreement.

Tuesday, October 22, 2019

Mozart3 essays

Mozart3 essays I'm writing my paper on Wolfgang Amadeus Mozart. I will be talking about his life and his music. I will tell you a little bit about his father, wife, Mozart was the leading composer of the Classical Age. He wrote many different types of music. He was the best composer of his time. Mozart was born in Salzburg, Austria on January 27, 1756. He was around music his entire life. By the age of three, he had begun to show a love of music. He would listen to his sister play the piano for hours at a time. Then he would get up on the bench and try it himself. He loved to When Mozart was five, he was already doing plays. He took part in a comedy called Sigismundus Hungariae Rex. Just after this he began to travel around Europe to play pieces of his music for kings. By this time in his life, he was already composing operas for the theartre. Mozart composed over six-hundred pieces, some of which he composed by the age of fourteen. He appreciated music because his father also loved and appreciated music. His father's name was Leopold. Leopold was a great composer as well as a leader of a social party. Mozart and his father traveled together to play music. His sister Nannerl, whom Mozart had listened to in his child years, usually came along to support Leopold and Mozart had different styles of music. Leopold only composed religious music. Mozart wrote operas, symphonys, church music, concertos, and also serenades. He excelled in all types of music. Mozart never rewrote any of his work. It was always perfect the first time. He never recopied his work either. There was only one original copy of each of his works. Now of course they have been recopied and sold in People loved to be around Mozart. He had a wonderful sense of ...

Monday, October 21, 2019

Double Comparative in English Grammar

Double Comparative in English Grammar The double comparative is the use of both more (or less) and the suffix -er to indicate the comparative form of an adjective or adverb. In present-day standard English, double comparatives (such as more easier) are almost universally regarded as usage errors, though the construction is still heard in certain dialects. Examples Some-a people think Im more dumber than them because I dont talk so good, but they only know one language and meI speak-a two. (Marjorie Bartholomew Paradis, Mr. De Lucas Horse, 1962)I was more tireder than ever Id been in my life, wore down beyond weariness. (Ron Rash, One Foot in Eden. Macmillan, 2004)But the only thing I got to tell you, if you take a dog and kick him around hes got to be alert, hes got to be more sharper than you. Well, weve been kicked around for two thousand years. Were not more smarter, were more alert. (Mordecai Richler, Barneys Version. Chatto Windus, 1997)Repose you there; while I to this hard house- More harder than the stones whereof tis raised. (Kent to King Lear in Act Three, scene 2, of King Lear by William Shakespeare) The Taboo Against This Belt-and-Suspenders Usage Double comparison is taboo in Standard English except for fun: Your cooking is more tastier than my mothers. I can see more better with my new glasses. These illustrate the classic double comparative, with the periphrastic more or most used to intensify an adjective or adverb already inflected for the comparative or superlative. A belt-and-suspenders usage, this is a once-Standard but now unacceptable construction (like the double negative) that illustrates yet again our penchant for hyperbole. Shakespeare (the most unkindest cut of all) and other Renaissance writers used double comparison to add vigor, enthusiasm, and emphasis, and so do young children and other unwary speakers of Nonstandard English today. (Kenneth G. Wilson, The Columbia Guide to Standard American English. Columbia University Press, 1993) The Double Comparative in Early Modern English As was true in earlier times also, a good many instances of double comparisons like more fitter, more better, more fairer, most worst, most stillest, and (probably the best-known example) most unkindest occur in early Modern English. The general rule was that comparison could be made with the ending or with the modifying word or, for emphasis, both. (Thomas Pyles and John Algeo, The Origins and Development of the English Language. Harcourt, 1982) More and most were historically not comparative markers, but intensifiers (as they still are in such expressions as a most enjoyable evening). In EMnE [Early Modern English], this intensifying function was felt much more strongly; hence writers did not find it ungrammatical or pleonastic to use both a comparative adverb and s from Shakespeare include in the calmest and most stillest night and against the envy of less happier lands. (C.M. Millward, A Biography of the English Language, 2nd ed. Harcourt Brace, 1996) More Doubles in English Grammar Double NegativeDouble Superlative

Sunday, October 20, 2019

Foo Fighters and UFOs

Foo Fighters and UFOs Foo Fighters and UFOs Foo Fighters and UFOs By Maeve Maddox Only recently have I come across the delicious term Foo Fighter. foo fighter: Any of various unidentified lights encountered by airborne forces during the Second World War (1939-45), interpreted variously as enemy weapons, natural phenomena, or alien spacecraft. OED According to a lengthy and informative article at Answers.com, foo fighters were seen at sites all over the world during World War II: 1941: Indian ocean: 1942 Java Sea, Solomon Islands 1945 France The etymology of foo fighter is uncertain: The term is generally thought to have been borrowed from the often surrealist comic strip Smokey Stover. Smokey, a firefighter, was fond of saying, Where theres foo theres fire. (This foo may have come from feu, the French word for fire, or Feuer the German word for fire, or from Smokeys pronunciation of the word fuel.) A Big Little Book titled Smokey Stover the Foo Fighter was published in 1938. Foo may alternatively have come from either of the French words faux meaning fake, or fou, mad. Answers.com The term flying saucer to describe an unidentified flying phenomenon dates from 1947. The term Unidentified Flying Object dates from 1950; the first documentation of the abbreviation UFO is from 1953. The abbreviation led to the coining of the unlovely word Ufology: the study of UFOs. Perhaps because UFO carries connotations of craziness, a new acronym has come into use: UAP, Unidentified Aerial Phenomenona. There’s a National Aviation Reporting Center on Anomalous Phenomena dedicated to the study of UAP sightings. Whatever you call them, these strange aerial phenomena have been around for a very long time. Want to improve your English in five minutes a day? Get a subscription and start receiving our writing tips and exercises daily! Keep learning! Browse the Expressions category, check our popular posts, or choose a related post below:Direct and Indirect ObjectsEnglish Grammar 101: Verb MoodThe "Pied" in The Pied Piper

Saturday, October 19, 2019

What are the tradeoffs between relational and object-oriented Essay

What are the tradeoffs between relational and object-oriented databases and database management systems - Essay Example This section also outlines tradeoffs between relational, object-oriented databases and database management systems. RDBMSs (Relational Database Management Systems) have been offering excellent services and benefits to their users; however this achievement is incomplete as well as limited to only some kinds of applications. In view of the fact that the business clients adopt latest versions of systems, as well as develop to previous ones, their efforts to make use of RDBMS come across the "Relational Wall," where RDBMS technology is no longer capable to offer the functionality and services required by the users. Additionally, users face this barrier when they try to enlarge information models to sustain associations among data, novel data types, extensible data types, and straight support of data objects. In the same way, the barrier can take place when implementing database in distributed environments through complicated processes. On the other hand, attempts to resolve these issues with relational technology cause an explosion of tables, a lot of joins, deprived performance, unfortunate scalability as well as loss of integrity. Thus, ODBMSs present a path further than the wall (Objectivity, Inc., 2005). Additionally, the emergence of new generation of Relational Database Management Systems has offered a lot of advantages to clients. These advantages comprise unplanned query, self-governing data from logical application, and a variety of front-end GUI (graphical user interface) systems. In addition, it has also offered many business applications, as well as the business sector has expended to over $4B yearly, comprising tools. There is a question that why we should look beyond RDBMSs? We should perform so simply when essential to capability and support of new types of systems, new associations, distribution, media data types as well as scalability. In reality, the majority of systems and applications have never made use of RDBMSs, and a lot of applications that have utilized RDMBS are now searching for other options, like that ODBMSs (Objectivity, Inc., 2005). In addition, the relational databases have offered a high-quality service in a lot of customary database systems. Despite the fact that, in many scenarios for instance when it is complicated to deal with information, or when superior efficiency is needed (i.e. objects having anonymous identifiers, or objects going from one type to another, etc.), or when we need to manage non-conventional data (such as images, long texts, etc.), additional techniques need to be implemented. Normally, these techniques include object-oriented or semantic databases. Additionally, the semantic database models are object oriented database models. Moreover, they present, a variety of levels, a lot of characteristics of semantic models, in the form of conceptual information, as well as, purify a number of behavioral characteristics of the data (Rishe, 2010). However, if a RDBMS can resolve our problems without numerous efforts as well as offers the required results, efficiency and scalability then there is no need to utilize an ODBMS. If some of the below given situations are convened then we should think about using ODBMS. Belo w are some of the important reasons that require us to make use of RDBMS: (Objectivity, Inc., 2011) Complicated Relationships: If we are having numerous many-to-many relationships in our database, tree arrangements or network (graph) formations (Objectivity, Inc., 2011). Complicated Data Arrangement: If the data has numerous changeable length parts, such as arrays of structures, multi-dimensional arrays or binary streams (Objectivity, In

Friday, October 18, 2019

Admission Essay Personal Statement Example | Topics and Well Written Essays - 250 words

Admission Essay - Personal Statement Example n identifying major failures of businesses that have taken place throughout the history and it will even help me analyze how corporate governance and better corporate practices can assist organizations in avoiding such failure and save one self from entering the phase of bankruptcy in case of complete failure. This course will even help me in learning how organizations from different fields such as steel and auto industry have failed and what the repercussions of these failures were. In these subjects I will even learn what other options are available to organizations other than accepting bankruptcy. Assignments that I will do during these courses will help be conduct in-depth research in the field of corporate governance as well as organizational restructuring. These subjects along with various other legal topics and courses will assist me in understanding the technical details of law and the rules and regulations surrounding business environment. In future I aim at working for the legal department of an organization and want to ensure that the organization experiences success under my

The Importance of Reflection in Nursing Practice Essay

The Importance of Reflection in Nursing Practice - Essay Example This process, called a meta-cognitive process, is normally reflected in a number of our daily routines and activities. Thus when we have to attend a call from a patient in pain, what priority we accord to it will be determined by the values and beliefs we hold and how we assess the situation. Reflective learning calls for instilling of the critical nursing skills in nurses through participative and emancipative education. This in turn helps in empowering the practitioners to deal with contradictory situations. Such training implies learning continuously with regular evolutionary inputs. Daloz (1986) describes the characteristics of support and challenge and the ways in which they might combine to foster learning. He describes support as an affirming activity. When a teacher supports a learner, the teacher lets the learner know that the learner is cared about. White (1997) suggests that new knowledge and theory can be generated when a structured and analytical methodology is applied to reflect on experience. In general, reflective practices can be categorized in two types; Reflection-in-action is when someone is working, and learning at the same time i.e. being fully aware of he's doing. Reflection-on-action is learning in a simulated environment when the nursing practitioners are taught by their tutors with the help of practical. For example nursing calls for advice being offered to the relatives and friends of the patients. Nursing is a science as it requires studying the medical practices and science, but it's an art as well because working with different types of people requires an attitude of understanding the feelings and compassion. Profession of Nursing involves being well versed with the technical gadgets, bio-medical terms, clinical tests, test reports as well as psychology, since during the majority of the times, when doctors are not around, nobody from family or friend circle is nearby, a Nurse is supposed to be the bedside companion taking care of the person with all sincerity. During such times most of our behaviors represent a mixture o f influences from both implicit, subconscious activations, and conscious considerations. The profession often requires long hours of working and heavy workloads while dealing with a range of people from all walks of life. Therefore, reflection-in-action is observing the things and the surroundings from one point of view and then devising 'in-time' appropriate reflections. Therefore in my opinion the profession of nursing requires; Compassion for another's suffering and love for the feelings of their patients Very high ethical standards Commitment to their profession Good interpersonal communication ability Critical cognitive process based thinking ability Highest standards of integrity and honesty Dealing with difficult and often unpleasant circumstances Working in physically demanding and often stressful environment Continuous aptitude for learning throughout one's life. Schon (1983) therefore calls for a "reflective practicum" to be an integral part of professional education. Lamb & Huttlinger, (1989) advocates reflection has a method by which nurses can enhance their future prospects and research practices. Williams (2001) enlists the results of a survey

Thursday, October 17, 2019

Defining the Good Life Essay Example | Topics and Well Written Essays - 1000 words

Defining the Good Life - Essay Example Wealth, health, a life without sorrow and pain are some of what seem to give people satisfaction, one that is said to be a good life. Perhaps it is. For the Greeks, a good life is one that shows happiness. It is then a matter of getting the most of what one has. For instance, a person who is lacking in wealth, according to the definition of the Greeks, can still have a good life depending on how he lives his life. That certain individual can either live in misery which is the extreme opposite of a good life or live so that he would make his life worthwhile and productive, a life that is flourishing. Human flourishing is a wonderful parallelism of the Greeks to a good life because it is perhaps the most accurate or closest accurate definition. Growing well is indeed one of the measures that show how a life is well-lived. It is not just a matter of living in luxury but it is also how a person lives to acquire a luxurious life, having the virtues a good life brings. This means that, in the case of wealthy people, they should not just enjoy what they have but strive to maintain and grow their wealth. However during the process, they should also maintain ethical attributes to keep them proud and satisfied with their achievements. When a person progresses or gains more wealth through illegal means or by using and abusing other people; that individual will definitely feel ashamed of himself. In fact, people who prosper in such a manner always live in fear of government authorities or their rivals and the people they have hurt. They may live in luxury, have money to burn but they do not have a good life because of the absence of the virtues they should possess. As the famous Socrates said, â€Å"The unexamined life is not worth living for† (facultyfiles.frostburg.edu). Indeed, when an individual does not examine himself, he tends to commit mistakes and repeats them time and again. Obviously, a life full of mistakes and without virtues is miserable and undesirabl e. It is not a good life. Being a philosopher, Socrates was actually pointing out to the critical examination of things, events and ideas, the contemplation, self-examination and open-minded wondering (facultyfiles.frostburg.edu) that lead to finding the reasons for everything. A good life is a life of reasonable reasons. Reasons abound but if they are well thought, they make sense and therefore show the energy put into it. However, when reasons are shallow, they often look and sound ridiculous, exposing the life of the person that is not worth living. In relation to the aforementioned discussion on having virtues, it is acquired by having a well-examined life. One who thinks about himself and knows his strengths and weaknesses would definitely be able to build up the strengths and work on his weaknesses in order for him to become a better person. For instance, when a person knows that he has talents in arts, he can do something to develop his gift and become skillful and successful regardless of his situations. A person who knows he is gifted but does nothing to improve it spends no time contemplating about what a privilege he has, has a life not worth living. Self-examination in itself is a virtue and indulging in it develops more virtues in an individual. For example, a man who examines himself develops honesty. It would be futile to examine one’s self and deny what he sees because this will cause a person to lose his virtues instead of gaining them. However, if a man scrutinizes himself and recognizes and accepts his weaknesses and faults, positive changes follow which is the development of more virtues that show what a real good life

Week11 Essay Example | Topics and Well Written Essays - 250 words

Week11 - Essay Example The government has to develop constituents within its establishments that have been in charge of state-owned companies. These branches eventually outlive their usefulness thus a disadvantage to the government because then it would have to do away with them. This means many people will lose their jobs thus blame the government for its shortsightedness (The Economist Debate). The limitation to state capitalism is that it can only be productive in certain industries as chosen by the government while the rest remain out. However, this depends on the degree of management as well as the level of interference by the state in the operational matters of the industries involved. All in all, the success or failure of state capitalism depends on the state and countries should know their status before indulging themselves or else the economy would be disastrous. In this case, the private sector would suffer a lot as its fundamental liberties would undergo regression. A country such as China is undergoing fast, economic growth thanks to state capitalism. However, its exposure to fluctuations in the purchasing power of other economies makes it unstable and

Wednesday, October 16, 2019

Defining the Good Life Essay Example | Topics and Well Written Essays - 1000 words

Defining the Good Life - Essay Example Wealth, health, a life without sorrow and pain are some of what seem to give people satisfaction, one that is said to be a good life. Perhaps it is. For the Greeks, a good life is one that shows happiness. It is then a matter of getting the most of what one has. For instance, a person who is lacking in wealth, according to the definition of the Greeks, can still have a good life depending on how he lives his life. That certain individual can either live in misery which is the extreme opposite of a good life or live so that he would make his life worthwhile and productive, a life that is flourishing. Human flourishing is a wonderful parallelism of the Greeks to a good life because it is perhaps the most accurate or closest accurate definition. Growing well is indeed one of the measures that show how a life is well-lived. It is not just a matter of living in luxury but it is also how a person lives to acquire a luxurious life, having the virtues a good life brings. This means that, in the case of wealthy people, they should not just enjoy what they have but strive to maintain and grow their wealth. However during the process, they should also maintain ethical attributes to keep them proud and satisfied with their achievements. When a person progresses or gains more wealth through illegal means or by using and abusing other people; that individual will definitely feel ashamed of himself. In fact, people who prosper in such a manner always live in fear of government authorities or their rivals and the people they have hurt. They may live in luxury, have money to burn but they do not have a good life because of the absence of the virtues they should possess. As the famous Socrates said, â€Å"The unexamined life is not worth living for† (facultyfiles.frostburg.edu). Indeed, when an individual does not examine himself, he tends to commit mistakes and repeats them time and again. Obviously, a life full of mistakes and without virtues is miserable and undesirabl e. It is not a good life. Being a philosopher, Socrates was actually pointing out to the critical examination of things, events and ideas, the contemplation, self-examination and open-minded wondering (facultyfiles.frostburg.edu) that lead to finding the reasons for everything. A good life is a life of reasonable reasons. Reasons abound but if they are well thought, they make sense and therefore show the energy put into it. However, when reasons are shallow, they often look and sound ridiculous, exposing the life of the person that is not worth living. In relation to the aforementioned discussion on having virtues, it is acquired by having a well-examined life. One who thinks about himself and knows his strengths and weaknesses would definitely be able to build up the strengths and work on his weaknesses in order for him to become a better person. For instance, when a person knows that he has talents in arts, he can do something to develop his gift and become skillful and successful regardless of his situations. A person who knows he is gifted but does nothing to improve it spends no time contemplating about what a privilege he has, has a life not worth living. Self-examination in itself is a virtue and indulging in it develops more virtues in an individual. For example, a man who examines himself develops honesty. It would be futile to examine one’s self and deny what he sees because this will cause a person to lose his virtues instead of gaining them. However, if a man scrutinizes himself and recognizes and accepts his weaknesses and faults, positive changes follow which is the development of more virtues that show what a real good life

Tuesday, October 15, 2019

INTERNATIONAL STUDIES IN BUSINESS Assignment Example | Topics and Well Written Essays - 250 words - 2

INTERNATIONAL STUDIES IN BUSINESS - Assignment Example My classmate does not show clearly whether the point on U.S restricting trade explains hurting or helping the auto industry. Although from the example given, one can conclude that he or she was talking about hurting the auto industry because the example shows that restricting imports would reduce innovativeness of auto industry. My classmates second answer is partly correct and partly out of context in addressing the question. He or she is correct by saying that autoworkers will be helped by the US’s efforts to restrict imports. The fact that foreign auto companies have branches in the US means that employment is made available to the US citizens. I do not agree with the idea that foreign companies such as Honda and Toyota hire only Japanese workers. The point on sales in Honda and Toyota cars going down and influencing the industry is out of context because it does not relate to government restricting imports. The point on government influencing auto industry is also not clear by not mentioning whether the policies created regard imports and exports according to the question. The point on manufacturers being forced to build safer and fuel efficient cars is also out of context. I think my classmate misinterpreted the

Monday, October 14, 2019

Deception in Psychological research Essay Example for Free

Deception in Psychological research Essay Deception in psychological research usually entails tricking people so that the researchers can get the answers they need or ascertain why things happen the way they do. There are many controversial topics in psychology and all of them seek to explain the things in our environment and people’s behavior. One of these controversial topics is hypnosis usage under cognitive psychology. Hypnosis is a good way of assisting in repressed memories. It has assisted many people in therapeutic procedures but its effectiveness is sometimes questionable by others. Hypnosis as a way of facilitating repressed memories Hypnosis is a form of Recovered Memory Therapy that helps a person with memory relapse to recall information that they cannot remember. A person does not necessarily mean that someone is asleep. Therefore it is a state between being awake and asleep. Trances serve as an example of hypnotic functions. Though they serve similar purposes, trances need to be differentiated from hypnosis because they are done deliberately as used in clinical procedures to help people with memory loss or lapses to regain them. The sympathetic nervous system controls arousals while the parasympathetic nervous system relaxation. These two systems do not function at the same time. When people are in the hypnotic state, they give up their consciousness and accept the inner truth (Richard, 1998). A person can undergo a deep trance where a person or the hypnotist facilitates the process or a lighter trance referred to as self hypnosis which individuals can create by themselves. This is where a person creates their own visual memory via meditation, listening to soft music or some other ways while maintaining a certain level of consciousness. Negative hypnosis occurs when people are easily influenced by what others say and the things they are exposed to. If people are told that they are not able to do certain things and they believe in such comments, then there is a likely hood that they will not accomplish they thing they have been discouraged. This is what constitutes the negative hypnotic state. Therefore, hypnosis is about expectations. If a person has positive expectations, then they can achieve any thing that they set for themselves but if they are negative, they are more likely to fail at whatever they decide on. Health care practitioners can therefore enhance the well being of their patients by assisting them in increasing their positive expectations. Hypnosis is important in helping sick with psychogenic amnesia or people who have lost their blocked certain memories as a result of traumatic experiences. It has been seen to work well for such patients. Research has shown some cases like child sexual as well as physical abuse can be forgotten. Likewise, evidence of recovery of the memories has also been shown (APA, 2001). At first, when the memory is being got, it presents itself in bits and pieces therefore more sessions with the person have to be conducted so as to help in recovering the memory. Traumatic memories often present themselves in a different manner than ordinary experiences. This is because this form of extreme information can interfere with other brain functions. Studies have suggested that traumatic memories that have been recalled are just as accurate as the traumatic memories that have been forgotten. Case study To examine whether hypnosis is an effective way of facilitating repressed memories, a study was conducted by Widom and Morris in 1998. The study included 23 adults; 12 females and 11 males who had been exposed to childhood abuse experiences and had repressed memory lapse in over 15 years. This group underwent hypnotic therapy for a period of three months (Widom Morris, 1998). From the study, it was seen that the there is a difference in the way of recalling events between the women and the men. The women were willing to share the little pieces of information that they could recall but the men were not. This influenced the hypnotic procedures because little memory was collected on most of the males as compared to the women. As the sessions progressed, there were slight improvements in memory and this can be attributed to the intense impact of the traumatic experiences on the victims as was seem from those who managed to get some of their memory back. At the end of the study period, 53% of the women and 42% of the men had recovered their memory and were satisfied that it as true. A quarter of those studied who managed to get their memory back had rejected their results saying that they may be false while the remaining never really got their memory back but said that so far they were pleased with their lives and would not engage in any other tests. From the study, we can say that hypnosis does work and can help people regain the memory they have lost. As the process was underway, most of the patients had a positive change in their personality as they said that they were more engaged in community activities as they were encouraged by the test takers. At the end of the study period, approximately half of the patients had got their memory back and this shows that if the procedures are done well and for a longer period, then people with previous traumatic incidents that need recovery can gain their memory back. About 25% of the individuals said that they usually kept to them selves and this can be a contributing factor as they do not trust the therapists to help them recover the memory. Various studies have also shown that events in a person’s life influence their behavior as well as interpersonal relations with others. From the above case, the unwillingness of some clients to share basic information limited the process. Some of those who refused said that as much as they wanted to get their memories back, said that it would probably affect them in a negative way. If they did, the numbers would have definitely increased. â€Å"There is conflict between the in formation a person wants to know and what they would like to forget all together. Some people may remember too much too little and this may be good or bad depending on the context they are presented (Herman, 1995). † Nowadays, some people feel that there are not enough scientific research studies to back up the credibility of the various research memories. Others continue to say that one cannot completely tell whether the results got are true or of they are based on what the hypnotist has been telling them. Even when the patient who agrees that the memory that they got was false, their condition can be worse when they suffer Post traumatic Stress Disorder. Some fear the use of hypnotic procedures on children because it would affect them psychologically and this is not helping in improving their situation. †This kind of therapy confuses the mind as a person cannot tell the difference between what is real and imaginative and this has further contributed to the destruction of families (Rivera, 1993). † In addition, they can deny certain memories because of guilt, the need to protect their families or may be reacting according to the stress levels they have been exposed to. The False Memory syndrome Association says that they have a lot of cases that are taken to court have shown that that some therapists are liars as they implant false memories on their patients (Thierry Spence, 2004). With the increase in such cases, some judges refuse getting evidence that has been recovered through hypnotic procedures. â€Å"Such methods of treatment have therefore also not been fully accepted in science as well as psychology (Schacter, 1996). † In 1997, according to the U. S bureau of Justice statistics report on a survey of female inmates in jail, it was found that 36% of them had been abused when they were young and one third of them has been raped they were imprisoned. And further 16 case studies on child abused individuals for comparison was undertaken and it showed that about 15% of them were abused as children. This shows that as much as the experiences can be traumatic, not all of them are forgotten and if, they have been suppressed by the individual but they can be retrieved if proper therapy is used. Individuals can recollect a few things and these bits are necessary in the formation of the bigger picture. The few loopholes in research should not be a foundation for dismissing hypnosis in retrieving repressed memories. People have had serious accidents and this form of therapy has helped some who medication did not help in regaining their memories back. Hypnosis therapy is a powerful mechanism as it enables people to regain memories that they thought they could never regain as well as achieve certain goals they have set for themselves. â€Å"This power and acceptance of hypnosis as a form of therapy is due to the fact that it deals with capabilities which appear to be beyond normal activities (Hopper van der Kolk, 2001). † Moreover, it gives people power to discover their inner being and stop actions such as smoking, drinking and other forms if addictions. Hypnosis also serves as a motivation for people’s engagement in physical activities and aids in reducing stress. This kind of therapy is helping in treating illnesses and certain disorders (De Vos Louw, 2008). Hypnosis is also used as a form of therapy in children as a form of helping in changing their behavior and assisting in improving their health. In addition, hypnosis enhances personality enrichment by improving people’s self esteems, self confidence such that they get the courage to speak out in public when initially they could not. â€Å"Weight loss motivation, healthy eating and exercise, better sleep for people with seeing disorders, controlling anger, and controlling peoples fears among other things (Thierry Spence, 2004). † Reliability and Validity of Research The study was reliable because the results indicated the specific responses of the individuals and since the study sample was small, it was easier to monitor individual progress. This would not have been the case if it were a larger number. Those individuals who were found out to have been sexually abused when they were young said that that was a possibility and most knew the individuals further proving that the results were reliable and valid. In addition, the individuals all showed up for the sessions as required therefore the lack of memory recovery could not be attributed to not attending the sessions. On top of these, no form of biasness was seen as the procedures were made as standard as possible and all variables that needed to be controlled were checked. Conclusion Hypnosis therapy usage is acceptable in society has it has helped a lot of people in more than one way especially in facilitating repressed memories. After all, the main goal of the procedure is to assist in the well being of a person. These form of therapy needs to be supported in increasing its evidentiary weight such that these memories can be used as evidence in the courts of law. Clinicians as well as psychotherapists therefore need to be skilled in this area for them to be able to properly guide the procedure so that the clients can get true memories which are part o their whole being and without them they are not complete. References American Psychological Association (APA) 2001. Understanding Child Sexual Abuse Rivera, Joseph. Trauma searches plant the seed of imagined misery, The Sacramento Bee, May 18, 1993. Herman, J. L. (1995). Crime and memory. Bulletin of the American Academy of Psychiatry and the Law, 23, 5-17. H. M. De Vos and D. A. Louw (2008). Hypnosis-induced mental training programmes as a strategy to improve the self-concept of students Vol. 57, No. 2, Higher education journal 2008 Hopper, J. W. , van der Kolk, B. A. (2001). Retrieving, Assessing, and Classifying Traumatic Memories. Journal of Aggression, Maltreatment, Trauma, 4, 33-71; and Freyd, J. F. , DePrince, A. P. (Editors). Trauma and Cognitive Science (pp. 33-71). Binghamton, NY: Haworth Press. Richard, S. C. July 1, (1998). The magic of hypnosis: is it childs play? The Journal of Psychology Schacter, Daniel L. (1996). Searching for Memory the brain, the mind, and the past. New York, Basic Books. Thierry, KL, Spence MJ (2004). Contemporary hypnosis Widom, C. S. Morris, S. (1998). Adult recollections of childhood victimization: Childhood sexual abuse. Psychological Assessment, 8, 412-421.

Sunday, October 13, 2019

Puumala Virus (PUUV) Genome Analysis

Puumala Virus (PUUV) Genome Analysis HANTAVIRUS PAPER REVIEW Summary A key concern of any viral vaccine research is the tremendous genetic diversity of the virus Hantaviruses are etiological agents generally known to cause two distinct human diseases: kidney affecting disease and heart affecting disease, haemorrhagic fever with renal syndrome (HFRS) sometimes called Nephropaphia epidemica (NE) in Eurasia and Americas hantavirus pulmonary syndrome (HPS) respectively. These viruses are heterologous (heterologous transmission from animals to humans (zoonosis)) which belong to the hantavirus genus, family Bunyavidae normally they make up four genera Hantavirus, Orthobunyavirus,   Nairovirus, Phlebovirus and Tospovirus. The genome of hantaviruses consist of three segments which are negative-strand of RNA, small (S) 1821-1830 nucleotides (nt), medium (M) 3682 nt and large (L) 6530-6562 nt encoding for nucleocapsid (N) protein, glycoprotein molecule (GPC) Gn, Gc proteins   and RNA-dependent RNA-polymerase, respectively. This study characterises the full genome of a Russian hantavirus discovered both in infected humans and small animals, Puumala virus (PUUV). PUUV is considered a prime etiological agent of hemorrhagic fever with renal syndrome sometimes referred to nephropaphia epidemica in Russia and Eurasia. Mostly, all hantavirus diseases in human have a fatality rate ranging from mild to severe with an intriguingly percentage rate from 0.1% up to 50%,   the symptom outcome of the disease   heavily depend on the geographic location of an infected person. Precisely, in the republic of Tatarstan, Russia the strain of Puumala virus has shown significance increase as human pathogens resulting to the acquiring of the status as emerging virus. PUUV in the republic of Tatarstan, Russia, has become a serious life-threatening hantavirus causing HFRS with high fatality rate of up to 12%, especially in the Volga region. The spectrum of illnesses caused by hantaviruses varies with the particular virus involved(Hantavirus infection: a global zoonotic challenge paper). It is reported that the high peak of Puumala virus comes with the high agricultural activities of this region during of which Bank vole mouse (Clethrionomys glareolus) the etiological agent of HFRS rapidly multiply. Normally, hantavirus, Puumala virus (PUUV) is transmitted to human by coming into contact with contaminated materials like faecal matter, blood dropped by an infected rodent and through aerosolised contaminated air and by bite of a carrier infected rodent. In the case of the strain of Puumala virus in the Republic of Tatarstan, Russia, the strain is dropped by notorious reservoir rodent specie found in the surrounding environment either near homes or in the fields, Bank vole mouse (Clethrionomys glareolus). It has to be noted here that most hantaviruses are transmitted to human by small animals themselves with an exceptional of Andes virus which can be transmitted from human to human. In South America the case of Andes virus has been reported to be transmitted from human to human. Intriguingly, other species of hantaviruses, Dobrava-belgrade (DOBV) virus with its sub-species isolated in Europe, and Tula virus (TULV) are seriously detected and isolated in Russian and know to cause hemorrhagic fever with renal syndrome (HFRS) and in Europe the syndrome is called Nephropaphia epidemica. Dobrava-belgrade is known to be associated with yellow naked-mouse (Apodemus flavicollis) this specie is the most life-threatening hantavirus. Other dobrava-belgrade species, DOBV-Af, DOBV-Aa and DOBV-Ap are associated with A. flavicollis (Af), A. agrarious (Aa) and A. ponticus (Ap) respectively. All these species cause HFRS from mild to severe mode of disease. PUUV form distinct phylogenetic leanage, in line with the natural host, bank vole (Clethrionomys glareolus). The strain of Puumala virus is heavily isolated in Ufa, Samara,..parts of Russia both in human and small animals, in human as they thrive causing the dangerous form of human disease, hemorrhagic fever with renal syndrome (HFRS) Introduction Hantaviruses If you hear a feminine voice thinks of a beautiful lady, what if this time the feminine voice is of a man [1]. Hantaviruses have been limited to the genus hantavirus under bunyaviridae family which give rise to several number of species viruses Puumala virus (PUUV) [2], Dobrava virus (DOBV), Tula Virus, puumala virus (PUUV) Saaremaa virus (SAAV), and Seoul virus (SEOV) are commonly know hantaviruses to be circulating in Europe and Russia [3-5]. However, the agent rodents Hantaviruses are morphologically classified as follows; order rodential, families crecitidae and muridae. Its now a known fact that rodents are not the only hantavirus reservoirs. Researchers have found hantaviruses insects which belong to the lipotyphra order, soriciodae familys and Talpidae[6]. Further, with the recently isolated Bat-borne Hantavirus in China, laibin virus ( LBV) chyroptera order has given a strong predictive assumption that hanataviruses could be found in other animals like cow, [6]. The black bea rd tomb bat hantaviruses isolated in china gave a discrete relation to the previously known hantaviruses. Heavily depending on the geographical location of an infected person, the outcomes of hantavirus infection are well classified human diseases: haemorrhagic fever with renal syndrome (HFRS) sometimes referred to nephropathia epidemical mostly in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) normally called hantavirus pulmonary syndrome in the Americas [7] (dissertation Nina Luteka 2010). [1] As the onset of the diseases advances the changes in the vascular permeability is highly noticed, defects in platelet function and acute thrombocytopenia intrinsically can also be observed which is associated with high fever and hemorrhage. However, with the global health threat of hantavirus it has triggered serious research mainly focusing on the vulnerability of the endothelial cells when attacked by hantaviruses. Needless to say, less viral cytopathic effect is observed on the endothelial cells after hantavirus infection. (dissertation Nina Luteka 2010). The mechanism underlying these drastically changes in platelet as the pathogen advances drastically pooling down the immune system and how the hantaviruses trigger interference in the immune system greatly remain futile and poorly understood. hantaviruses have been discovered in insects which acts as the host vector (HO2), hantaviruses in the reservoirs cause asymptomatic completely they do not show any symptom in the natural host. We characterized genome of puumala virus discovered both in human and rodents Diseases Hantaviruses are zoonotic viruses that infect human through rodents contact; in rodents they dont cause diseases but when human come into contact with infected rodent through smelling the excretes or inhalation of infected hair from the rodents induces human diseases known as; Hemorrhagic fever with renal syndrome found in Europe, the agent viruses for this disease are: Dobrava virus (DOBV)-Belgrade, Puumala, Saaremaa, Sochi, and Seoul virus which is recently reported [8],these viruses are considered to be old world viruses, Bulgaria is one of the country were Hemorrhagic with renal syndrome is endemic but the virus has never been found in the natural rodent reservoir [8] however, Eastern Russia, Korea and China has the highest cases of HFRS caused by HTNV, SEOV, and ASV. Nephropathia epidemical diseases, a rodent disease found in human who gets infected after coming in contact with infected rodents and this disease has the symptoms of the hemorrhageic fever with renal syndrome which makes it to be referred to as same as hemorrhagic fever with renal syndrome [2] has continued to be life threatening in the republic of Tatarstan since its first identified in 1997. Epidemiological study on Nephropathia epidemical between 1997 and 2013 in the republic of Tatarstan, Russia gives an account that NE mostly affect male adults due to the agricultural activities during which myodes graleorus (bank vole) the natural reservoir of NE causing agents population increases [9]. It is revealed that the higher epidemic of hantaviruses in the Republic of Tatarstan is due to the supportive mating environment of small animals (bank voles) and increase in agriculture activities. Myodes galeorus shows high population rate during this time of agricultural activities and are a genetic variant prevalence for hantavirus in this region. However, the severity (or the fatality, the outcome) and the kind of disease or the infection involved mainly depends on several factors; The place infection take place The pathogenicity of the agents The genetic makeup (or the genetic predisposition of the host) Diversity of the agents [1] Geographical of the infection acquired Not all known rodent and insect hantaviruses cause disease in human [3] and the treatment for this dangerous hantavirus infection remains futile. The reasons for the variation of severity between virus species/genotypes and in individual patients are not yet known. Diverse determinants concerning virusand patient-specific characteristics may play a role in the pathogenesis. Differences in the use of entry receptors, in the regulation of cytokine response and in viral replication were described to be associated with pathogenicity [8-11]. Studies with genetic reassortants in vitro and in animal models suggest molecular determinants to be responsible for virulence [5, 12]. However, the speciesspecific factors of hantaviruses that are responsible for pathogenicity and clinical picture are not identified so far. Interestingly, the pathogenicity of related viruses of DOBV genotypes differs enormously with case fatality rates (CFRs) between 0.3%-0.9% for DOBV genotype Kurkino and 14.5% for DOBV genotype Sochi [13]. In addition to severe courses that are linked to specific virus species or genotypes, several serious cases were reported for infection with PUUV that usually causes a milder form of hantavirus disease [14, 15]. These infections often involve extrarenal manifestations [16, 17]. From (Clinical characterization of two severe cases of hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses Puumala and Dobrava-Belgrade genotype Sochi paper) Hantaviruses evolution Hantaviruses within the family bunyaviridae are different from other member viruses in the sense that they are roboviruses (ROdent-BOrne viruses) signifying that they are hosted by small animals which act as the host reservoirs (vector). Other bunyaviridae virus members are arborviruses (arthropod viruses) transmitted by arthropod to human [10-12] . the circulation of hantaviruses throughout the continent has been triggerd by a number of activities which account for from human movements to the events of the world. These activities also account for the evolution of hantaviruses. However, it is believed that hantaviruses co-evolved together with their reservoirs animal more than 10 million years ago. The genetic diversity of hantaviruses came about by genetic mutation on the genome of the virus producing quasispecies which happened through deletions or insertion of new nucleotides. It is further, shown that the genetic diversity came about by reasortments of the same two viruses genome within the host and by the homologous recombination of the viruses with each other [12-14]. Evolution of hantavirus in the host (rodents) depends on the number of factors which greatly help them to thrive as they live within the host rodents or insects these factors include: the destict environment which act as a life supporting of rodent, there events that are believed to contribute to the evolvement of different kind of rodents, such as glaciations events.   Deglaciation events triggered the movements of rodents in the northern hemisphere southern hemisphere as the small animals migrated from one place to the other caused mutation to occurred in the host themselves and equally in the strain producing distinct kind of hantaviruses in the end causing permanent genetic variations in the population of the hantaviruses. Needless to say, human do not act as the host range of hantaviruses instead they are dead-end point of hantaviruses. Thereafter, hantaviruses do not evolve after inf ecting human vectors, its either they die together with the an infected body or they are wiped off from the human body.[11] Symptoms PUUV -circulating in Northern and Central Europe, Baltics, the part of Russia Europe and the Alpe- Adrian region; High fever Back pain Renal impairment DOBV- mostly circulating in Balkan countries and Alped-Adrian region has the following symptoms Severe illness Hemorrhage High fever Acute renal failure Dialysis may be required Fatality rate reaches 10% PUUV -circulating in Northern and Central Europe, Baltics, the part of Russia Europe and the Alpe- Adrian region; High fever Back pain Renal impairment Structure (morphology) The new era of elucidating the etiological agent of human disease hemorrhagic fever with renal syndrome (HFRS), emerged when the strain of puumala virus was isolated from the Bank vole (Clethrionomys glareolus) in Europe 199.., and the discovery of the four canners hantavirus in USA 1996. However, thanks to the famous and prolonged scientific work of Lee at el who isolated the first agent of Korean hemorrhagic fever, hantaan virus, from the autopsy lungs of striped field mice (apodemus agrarius) in 1978 after two decades of work [15]. Hantaviruses virion is lipid enveloped, covered and protected by polymorphic protein membrane nucleoprotein. The virion of hantavirus species are spherical shaped 80-110 nm in diameter [16-19]. Tripartite segmented negative-sense single stranded RNA genome comprising small (S), medium (M) and large (L) [20-22]. Small (S)-segment is the smallest segment and encodes for the nucleoprotein of 1821-1830 nucleotides the protein have 433 amino acids (aa) [22-2 4]. Medium (M)-segment encodes for the glycoprotein, large (L)-segment encodes for the RNA dependent RNA-polymerase (RdRp), of 3682 nt the glycoprotein precursor which covers the medium segment has 1148 amino acid, RdRp have 2156 aa, respectively [22-24] [6-10]. Furthermore, the small (S) segment however, has further an overlapping open reading frame (ORF) with a putative NSs protein of 90 aa [16, 20, 22, 24, 25] The lipid envelope bounded with viral glycoproteins covers nucleocapsids and RNA dependent RNA-polymerase.   Transmission The transmission of hantaviruses is done horizontally in specific human become affected by inhalation contaminated air, smelling of excreta of infected rodents and by direct contact with infected rodents. This can be realized through different situations: first domestication situation were an infected rodent happen to be in the house and leave some excreta, when in habitant come into contact with these materials they become infected, secondly through camping and agriculture this kind of situation amount to 70% of all kind of situation where people become infected. Natural reservoir Puumala virus is known to be harbored by the wild small animal called bank vole, myodes glareolus, DOBV, yellow field mouse; apodemus flavicollis, HTNV and a SAAV striped field mouse, apodemus agrarius (koreae and agrarius, respectively). SOCHV caused by black sea mouse, Apodemus ponticus; ASV Korean mouse field, apodemus penisulae; SEOV Norway rats, rattus norvegicus [3, 8] Hantavirus history Within a century modern world renascence between 1900 and 2000 the world witnessed the two major outbreak of diseases designated hemorrhagic fever with renal syndrome, sometimes referred to nephropathia epidenmica and cardiopulmonary syndrome all presumably caused by small animal rodents. The outbreak caused global human health threat before its agents where properly defined. It became an emerging potential human biological weapon disease because of its mass infections and its anthropoid vector which lead to the virus to thrive in its host reservoirs, without showing any sign of infection. The health hazardous outbreak led to the discovery of hantaviruses worldwide later categorized into two old and new world hantaviruses. Needless, to claim that hantaviruses evolutionarised only between this period, the signs and symptoms of these etiological agents disease in human hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome where long ago described noticed and can be seen in Chinese literature of 10th century and the Russian archives show the description of the disease as early as 1913 in Vladivastok. Lee et al, while working on the early reported severe or mild form of hemorrhagic fever, isolated the etiological agent believed to have induced high fever called Korean hemorrhagic fever near Hantaan River, Korea in 1978. The initial isolation of the agent of KHF led to the designating name hantavirus derived from the hantaan river the place where it was discovered. The highly published anticipated discovery of 1978 proved the earlier noticed hemorrhagic fever in 1951-1953 and gave the new era in the understanding of etiological agents human disease, HFRS and HPS in the world of health hazardous biological weapon. Needless, to say more than 3000 UN soldiers were diagnosed with high fever in the course of Korean War which lasted for 3- 4 years from 1951-53. Throughout, decades of research these zoonosis viruses were not well known However, afte r thorough research, until late 1981 the virus was known to have its own clade and belonged to bunyaviridae family, unlike other viruses hantaviruses research revealed that they did not have arthropod vector, hence they formed their own genus of hantavirus in the family bunyavidae and they exclusively maintained their residing reservoir rodents. Hence the new zoonotic Hantavirus emerged and was restricted to the old world viruses. This was proved wrong in 1993, the world experienced the outbreak of hantaviruses related diseases which triggered the malfunction of the respiratory system, high fever and severe heart damage in the unfortunate patients infected with hantaviruses. This lead to the conviction of world researchers that hantaviruses are actively circulating in the region earlier than there isolation in 1993, in the four corners of the Americas. Seoul virus transmitted by rat-borne mouse in Asia was described, an etiological agent specie of hantavirus causing HFRS in 1980 after the description of hantaan virus from striped field mouse (Apodemus agrarius) which started in 1976. This pioneered discovery came after a carefully long research and isolating the virus from the rat-borne mouse captured in the demilitarized battle field of Korea. The etiological agent of nephropaphia epidemical characterized in Europe was termed puumala virus, isolated from a bank vole striped field mouse initially called clethrionomys glareolus and later renamed myodes glareolus. 25 years later, the etiological agent of human disease hantavirus cardiopulmonary syndrome, Hantaan virus was identified from†¦..after the four corner outbreak in the united state in 1993 and this led to the discovery of another hantavirus specie called no name virus later renamed Sin Nombre virus. It is estimated that there hantavirus cases yearly go beyond 1500000 gl obally, with almost half of these cases occurs in the peoples republic of china. Since the definition of hantaviruses more than 22 species of hantaviruses known to be pathogen in humans have been clearly categorized and accepted by the international Committee of Virus Taxonomy. With the suspicions of been engineered spread the Center of Disease Control and Prevention (CDC) warn of hantaviruses to be possible potential biological weapons. The world health organization   in 1983 initiated the use of HFRS to represent all etiological symptomatic diseases believed to cause HFRS restricted in the Eurasia later called old world. Mostly, HFRS displayed symptoms such as chills, headache, high fever, generalized myalgia, back and abdominal pain and hemorrhagic presentation. Because of its epidemiological and worldwide distribution, hemorrhagic fever with renal syndrome initially had several names before 1983. Most terms used were epidemic hemorrhagic fever, Korean hemorrhagic fever and the alike symptomatic disease was called nephropathia epidemica in china, Korea and (USSR, Scandinavia and Europe) respectively. Hantaviruses clinical presentation Normally incubation of Hantaviruses human infection takes 2 to 3 weeks. The results of infection are the two distinct severe or mild forms of diseases: hemorrhagic renal with renal syndrome (HFRS) in the Eurasian countries and Hantavirus pulmonary syndrome in the American Countries. HFRS and Nephropaphia Epidemical are the severe form of hemorrhagic fever developed when infected with Euraisan kinds of Hantaviruses, patients present kidney failure, high fever, and internal bleeding as the main symptoms which results to the death of the patient[7]. Apart from kidney failure and high fever, affected humans present symptoms which include chills, vomiting, headache, dizziness, nausea, non-productive cough, gastrointestinal symptoms. A half percent of the patients display prolonged diarrhea, malaise and lightheadness, other presentations include back pain, arthralgias, abdominal pain, and shortness of breath, tachiypnea, tachycardia and fever. However, the main cause of death is the develo pment of disseminated intravascular congulation and internal bleeding. Table 1.   Clinical manifestation of Hemorrhagic Fever with renal syndrome [HemorrhagicFeverwithRenalSyndrome:PathogenesisandClinicalPicture Hong Jiang 1, HongDu1, LiM.Wang2, PingZ.Wang1* and XueF.Bai 1*] Incubation period takes 2-3 weeks HFRS Phase 1. Febrile Hemorrhage Flushing Headache Conjuctival injection Backache Albuminuria Azotema Present of antibodies IgM Eye pain Platelet decreased Petechial rash Immune complexes Fever Flushing Chills Conjuctival injection Myalgia Albuminuria Malaise Present of antibodies IgM Phase 2. Hypotension Kinin Complement activation Nausea Disseminated intrascular congulation Vomiting Vascular leakage Bleeding Acute shock Phase 3. Oliquric Disseminated intrasecular congulation (DI) Hypervolemia Kidney failure Pneumonia Phase 4. Diuretic Improved renal function Pulmonary complication Shock Death or improvement Phase 5. Convalescent Recovery period Table 2. Bunyavidae family classifications Common Reservoir Host Genus Common Species Country endemic Animal vertebrate bunyavirus Bunyamwera virus La Crosse virus Tahyna virus Akabane virus Oropouche virus Animal vertebrate Hantavirus Hantaan virus Sin Nombre virus Andes virus Puumala, Dobrava Americas Eurasia Animal vertebrate Nairovirus Dugbe virus Crimean-Congo hemorrhagic fever virus Nairobi sheep disease virus Eurasia, Africa Animal vertebrate Phlebovirus Rift Valley fever virus Rift Valley fever virus Sandly fever-Sicilian virus Plants Tospovirus Tomato spotted wilt virus Tomato spotted wilt virus Table 3: Hantaviruses genus classification Virus(serotype) Endemic area and reservoir distribution Disease Rodent vector Mortality (%) Puumala (PUUV) Eurasia (Old World) HFRS/NE Bank vole (Clethrionomys glareolus) 0.1-1 Dobrava-Belgrade (DOBV) South and East Europe, Balkan countries and the middle East (Old World) HFRS Yellow naked-mouse (Apodemus flavicollis) 9-12 Dobrava (DOBV) Central, East and north of Europe (Old World) HFRS Striped field mouse (Apodemus agrarius) Low Hantaan (HTN) Central, East and north of Europe, Eastern Russia,Tien Shan Mtns Caucasian,   China, north and south Korea (Old World) HFRS Striped field mouse (Apodemus agrarius) 10-15 Seoul (SEOV) World Wide (Old World) HFRS Rattus norvegicus and rattus 3-15 Tula (TUL) Europe (Old World) HFRS/? Microtus arvalis Low Amur Eastern Russia, Eastern Asia and Siberia (Old World) HFRS Korean field mouse (Apodemus peninsula) Low Andes (ANDV) South America (Argentina, Uruguay, Chile) (New World) HPS Oligoryzomys longicaudatus 35-56 Sin Nombre (SN) USA, Canada (New World) HPS Peromyscus maniculatus grassland 40-60 Prospect Hill(PH) (New World) USA, Canada HPS/? Mricrotus pennsylvanicus (Meadow vole) New York (NY) (New World) USA, Canada HPS Peromyscus   leucopus low Khabarosk (KHB) Russia , Asia (Old World) HFRS/? Microtus fortis (reed vole) low Thottapalayam (TPM) India, Afghanistan, Pakistan, China, Japan (Old World) HFRS/? Suncus murinus (musk shrew) Monongahela USA, Mexico, Canada (New World) HPS Peromyscus maniculatus (Deer mouse) low Black Creen Canal (BCCV) USA, Venesuala, Peru, (New World) HPS Sigmodon hispidus low Bayou   (BAYV) USA (Louisiana), (New World) HPS Oryzomys palustris Sigmodontinae (Rice rat) low Araraquara (ARAV) South America (Brazil) (New World) HPS Bolomys lasiurus low Muleshoe USA (New World) HPS Sigmodon hispidus Low Lechiguanas South America (Argentina), Brazil